CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations

CRISPR-Cas9 has been rapidly adopted to generate cell line models of disease. Here the authors show, while attempting to establish a congenital erythropoietic porphyria model, unexpected chromosome truncations generated by a p53-dependent mechanism.

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Autores principales: Grégoire Cullot, Julian Boutin, Jérôme Toutain, Florence Prat, Perrine Pennamen, Caroline Rooryck, Martin Teichmann, Emilie Rousseau, Isabelle Lamrissi-Garcia, Véronique Guyonnet-Duperat, Alice Bibeyran, Magalie Lalanne, Valérie Prouzet-Mauléon, Béatrice Turcq, Cécile Ged, Jean-Marc Blouin, Emmanuel Richard, Sandrine Dabernat, François Moreau-Gaudry, Aurélie Bedel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/3a225f969b444010a97c3369c573fb50
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spelling oai:doaj.org-article:3a225f969b444010a97c3369c573fb502021-12-02T15:35:11ZCRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations10.1038/s41467-019-09006-22041-1723https://doaj.org/article/3a225f969b444010a97c3369c573fb502019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09006-2https://doaj.org/toc/2041-1723CRISPR-Cas9 has been rapidly adopted to generate cell line models of disease. Here the authors show, while attempting to establish a congenital erythropoietic porphyria model, unexpected chromosome truncations generated by a p53-dependent mechanism.Grégoire CullotJulian BoutinJérôme ToutainFlorence PratPerrine PennamenCaroline RooryckMartin TeichmannEmilie RousseauIsabelle Lamrissi-GarciaVéronique Guyonnet-DuperatAlice BibeyranMagalie LalanneValérie Prouzet-MauléonBéatrice TurcqCécile GedJean-Marc BlouinEmmanuel RichardSandrine DabernatFrançois Moreau-GaudryAurélie BedelNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Grégoire Cullot
Julian Boutin
Jérôme Toutain
Florence Prat
Perrine Pennamen
Caroline Rooryck
Martin Teichmann
Emilie Rousseau
Isabelle Lamrissi-Garcia
Véronique Guyonnet-Duperat
Alice Bibeyran
Magalie Lalanne
Valérie Prouzet-Mauléon
Béatrice Turcq
Cécile Ged
Jean-Marc Blouin
Emmanuel Richard
Sandrine Dabernat
François Moreau-Gaudry
Aurélie Bedel
CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
description CRISPR-Cas9 has been rapidly adopted to generate cell line models of disease. Here the authors show, while attempting to establish a congenital erythropoietic porphyria model, unexpected chromosome truncations generated by a p53-dependent mechanism.
format article
author Grégoire Cullot
Julian Boutin
Jérôme Toutain
Florence Prat
Perrine Pennamen
Caroline Rooryck
Martin Teichmann
Emilie Rousseau
Isabelle Lamrissi-Garcia
Véronique Guyonnet-Duperat
Alice Bibeyran
Magalie Lalanne
Valérie Prouzet-Mauléon
Béatrice Turcq
Cécile Ged
Jean-Marc Blouin
Emmanuel Richard
Sandrine Dabernat
François Moreau-Gaudry
Aurélie Bedel
author_facet Grégoire Cullot
Julian Boutin
Jérôme Toutain
Florence Prat
Perrine Pennamen
Caroline Rooryck
Martin Teichmann
Emilie Rousseau
Isabelle Lamrissi-Garcia
Véronique Guyonnet-Duperat
Alice Bibeyran
Magalie Lalanne
Valérie Prouzet-Mauléon
Béatrice Turcq
Cécile Ged
Jean-Marc Blouin
Emmanuel Richard
Sandrine Dabernat
François Moreau-Gaudry
Aurélie Bedel
author_sort Grégoire Cullot
title CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
title_short CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
title_full CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
title_fullStr CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
title_full_unstemmed CRISPR-Cas9 genome editing induces megabase-scale chromosomal truncations
title_sort crispr-cas9 genome editing induces megabase-scale chromosomal truncations
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/3a225f969b444010a97c3369c573fb50
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