Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia

Abstract Background Ureaplasma urealyticum (UU) is found among the normal vaginal flora in a considerable proportion of asymptomatic women; however, adult central nervous system (CNS) infection of UU is extremely rare. Good's syndrome (GS) is an adult-onset immunodeficiency characterized by thy...

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Autores principales:	Ting Zhang, Haiyan Li, Shuping Hou, Huanxin Yu, Wei Yue
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ureaplasma urealyticum Meningitis Thymoma Hypogammaglobulinaemia Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/3a27b79d57a348a185cc25602bcd82dc
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spelling	oai:doaj.org-article:3a27b79d57a348a185cc25602bcd82dc2021-11-14T12:44:13ZCase report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia10.1186/s12879-021-06831-z1471-2334https://doaj.org/article/3a27b79d57a348a185cc25602bcd82dc2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06831-zhttps://doaj.org/toc/1471-2334Abstract Background Ureaplasma urealyticum (UU) is found among the normal vaginal flora in a considerable proportion of asymptomatic women; however, adult central nervous system (CNS) infection of UU is extremely rare. Good's syndrome (GS) is an adult-onset immunodeficiency characterized by thymoma, hypogammaglobulinaemia, low or absent B‑cells, and an inverted CD4+/CD8+ T‑cell ratio. Patients with GS usually have severe or recurrent infections. Case presentation We describe the case report of a 49-year-old woman who developed UU meningitis. Initial routine anti-viral and anti-bacterial therapy showed no improvement in the patient's condition. Next-generation sequencing (NGS) of cerebrospinal fluid (CSF) identified the UU DNA sequence. Accordingly, a diagnosis of UU meningitis was made, and minocycline therapy was initiated. The patient responded favourably, with no signs of disease at subsequent follow-up. According to the severity and rarity of the case, secondary immunodeficiency was suspected. Flow cytometry found hypogammaglobulinaemia. Combined with the previous history of thymoma, the patient was diagnosed with immune deficiency disease of GS. Conclusions This case may be the first adult case report in the literature describing UU meningitis in a patient with GS. The diagnosis of GS should be considered in patients presenting with unexplained antibody deficiency and thymoma.Ting ZhangHaiyan LiShuping HouHuanxin YuWei YueBMCarticleUreaplasma urealyticumMeningitisThymomaHypogammaglobulinaemiaInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-5 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ureaplasma urealyticum Meningitis Thymoma Hypogammaglobulinaemia Infectious and parasitic diseases RC109-216
spellingShingle	Ureaplasma urealyticum Meningitis Thymoma Hypogammaglobulinaemia Infectious and parasitic diseases RC109-216 Ting Zhang Haiyan Li Shuping Hou Huanxin Yu Wei Yue Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
description	Abstract Background Ureaplasma urealyticum (UU) is found among the normal vaginal flora in a considerable proportion of asymptomatic women; however, adult central nervous system (CNS) infection of UU is extremely rare. Good's syndrome (GS) is an adult-onset immunodeficiency characterized by thymoma, hypogammaglobulinaemia, low or absent B‑cells, and an inverted CD4+/CD8+ T‑cell ratio. Patients with GS usually have severe or recurrent infections. Case presentation We describe the case report of a 49-year-old woman who developed UU meningitis. Initial routine anti-viral and anti-bacterial therapy showed no improvement in the patient's condition. Next-generation sequencing (NGS) of cerebrospinal fluid (CSF) identified the UU DNA sequence. Accordingly, a diagnosis of UU meningitis was made, and minocycline therapy was initiated. The patient responded favourably, with no signs of disease at subsequent follow-up. According to the severity and rarity of the case, secondary immunodeficiency was suspected. Flow cytometry found hypogammaglobulinaemia. Combined with the previous history of thymoma, the patient was diagnosed with immune deficiency disease of GS. Conclusions This case may be the first adult case report in the literature describing UU meningitis in a patient with GS. The diagnosis of GS should be considered in patients presenting with unexplained antibody deficiency and thymoma.
format	article
author	Ting Zhang Haiyan Li Shuping Hou Huanxin Yu Wei Yue
author_facet	Ting Zhang Haiyan Li Shuping Hou Huanxin Yu Wei Yue
author_sort	Ting Zhang
title	Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
title_short	Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
title_full	Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
title_fullStr	Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
title_full_unstemmed	Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
title_sort	case report of ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia
publisher	BMC
publishDate	2021
url	https://doaj.org/article/3a27b79d57a348a185cc25602bcd82dc
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Case report of Ureaplasma urealyticum meningitis in a patient with thymoma and hypogammaglobulinaemia

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