A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice

Abstract Dengue viruses (DENV) cause an estimated 390 million infections globally. With no dengue-specific therapeutic treatment currently available, vaccination is the most promising strategy for its control. A wide range of DENV vaccines are in development, with one having already been licensed, a...

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Autores principales:	Jovin J. Y. Choo, Laura J. Vet, Christopher L. D. McMillan, Jessica J. Harrison, Connor A. P. Scott, Alexandra C. I. Depelsenaire, Germain J. P. Fernando, Daniel Watterson, Roy A. Hall, Paul R. Young, Jody Hobson-Peters, David A. Muller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3a288fab6e9c432db1197a1c7a39ffd8
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spelling	oai:doaj.org-article:3a288fab6e9c432db1197a1c7a39ffd82021-12-02T14:49:42ZA chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice10.1038/s41541-021-00328-12059-0105https://doaj.org/article/3a288fab6e9c432db1197a1c7a39ffd82021-05-01T00:00:00Zhttps://doi.org/10.1038/s41541-021-00328-1https://doaj.org/toc/2059-0105Abstract Dengue viruses (DENV) cause an estimated 390 million infections globally. With no dengue-specific therapeutic treatment currently available, vaccination is the most promising strategy for its control. A wide range of DENV vaccines are in development, with one having already been licensed, albeit with limited distribution. We investigated the immunogenicity and protective efficacy of a chimeric virus vaccine candidate based on the insect-specific flavivirus, Binjari virus (BinJV), displaying the structural prM/E proteins of DENV (BinJ/DENV2-prME). In this study, we immunized AG129 mice with BinJ/DENV2-prME via a needle-free, high-density microarray patch (HD-MAP) delivery system. Immunization with a single, 1 µg dose of BinJ/DENV2-prME delivered via the HD-MAPs resulted in enhanced kinetics of neutralizing antibody induction when compared to needle delivery and complete protection against mortality upon virus challenge in the AG129 DENV mouse model.Jovin J. Y. ChooLaura J. VetChristopher L. D. McMillanJessica J. HarrisonConnor A. P. ScottAlexandra C. I. DepelsenaireGermain J. P. FernandoDaniel WattersonRoy A. HallPaul R. YoungJody Hobson-PetersDavid A. MullerNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jovin J. Y. Choo Laura J. Vet Christopher L. D. McMillan Jessica J. Harrison Connor A. P. Scott Alexandra C. I. Depelsenaire Germain J. P. Fernando Daniel Watterson Roy A. Hall Paul R. Young Jody Hobson-Peters David A. Muller A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
description	Abstract Dengue viruses (DENV) cause an estimated 390 million infections globally. With no dengue-specific therapeutic treatment currently available, vaccination is the most promising strategy for its control. A wide range of DENV vaccines are in development, with one having already been licensed, albeit with limited distribution. We investigated the immunogenicity and protective efficacy of a chimeric virus vaccine candidate based on the insect-specific flavivirus, Binjari virus (BinJV), displaying the structural prM/E proteins of DENV (BinJ/DENV2-prME). In this study, we immunized AG129 mice with BinJ/DENV2-prME via a needle-free, high-density microarray patch (HD-MAP) delivery system. Immunization with a single, 1 µg dose of BinJ/DENV2-prME delivered via the HD-MAPs resulted in enhanced kinetics of neutralizing antibody induction when compared to needle delivery and complete protection against mortality upon virus challenge in the AG129 DENV mouse model.
format	article
author	Jovin J. Y. Choo Laura J. Vet Christopher L. D. McMillan Jessica J. Harrison Connor A. P. Scott Alexandra C. I. Depelsenaire Germain J. P. Fernando Daniel Watterson Roy A. Hall Paul R. Young Jody Hobson-Peters David A. Muller
author_facet	Jovin J. Y. Choo Laura J. Vet Christopher L. D. McMillan Jessica J. Harrison Connor A. P. Scott Alexandra C. I. Depelsenaire Germain J. P. Fernando Daniel Watterson Roy A. Hall Paul R. Young Jody Hobson-Peters David A. Muller
author_sort	Jovin J. Y. Choo
title	A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
title_short	A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
title_full	A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
title_fullStr	A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
title_full_unstemmed	A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
title_sort	chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a288fab6e9c432db1197a1c7a39ffd8
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A chimeric dengue virus vaccine candidate delivered by high density microarray patches protects against infection in mice

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