The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer

Abstract In this study, we determined the efficacy of the cell death biomarker cytokeratin 18 for diagnosing biliary tract cancer (BTC). We recruited 36 patients with BTC (Malignant group) and 45 patients with benign biliary tract disease (Benign group) for this study. We used M30 and M65 as cell de...

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Autores principales:	Mitsuru Sugimoto, Kazumichi Abe, Manabu Hayashi, Tadayuki Takagi, Rei Suzuki, Naoki Konno, Hiroyuki Asama, Yuki Sato, Hiroki Irie, Ko Watanabe, Jun Nakamura, Hitomi Kikuchi, Yuichi Waragai, Mika Takasumi, Minami Hashimoto, Takuto Hikichi, Yoshihiro Nozawa, Hiromasa Ohira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Cell Death Biomarkers Biliary Tract Cancer (BTC) Biliary Cytology Malignant Group Benign Biliary Tract Disease Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a2bfe63fe304f33a6de52b0dae27cfd
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spelling	oai:doaj.org-article:3a2bfe63fe304f33a6de52b0dae27cfd2021-12-02T15:08:11ZThe efficacy of serum cell death biomarkers for diagnosing biliary tract cancer10.1038/s41598-018-35278-72045-2322https://doaj.org/article/3a2bfe63fe304f33a6de52b0dae27cfd2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-35278-7https://doaj.org/toc/2045-2322Abstract In this study, we determined the efficacy of the cell death biomarker cytokeratin 18 for diagnosing biliary tract cancer (BTC). We recruited 36 patients with BTC (Malignant group) and 45 patients with benign biliary tract disease (Benign group) for this study. We used M30 and M65 as cell death biomarkers. M30 levels indicate apoptosis, and M65 levels indicate both apoptosis and necrosis. M30 and M65 levels were significantly higher in the Malignant group than in the Benign group (142.4 ± 117.0 vs 48.9 ± 71.2 U/l, P < 0.001; 1513.3 ± 837.4 vs 882.2 ± 831.2 U/l, P = 0.001). The diagnosability of M30 was the highest of the four markers (CEA, CA19-9, M30, M65) (cut-off value: 74.429 U/l, sensitivity: 72.2%, specificity: 77.1%, AUC: 0.771). The sensitivity of M30 (cut-off value: 74.429 U/l) was significantly higher than that of biliary cytology (76% (19/25) vs 12% (3/25), P < 0.001), and the accuracy of M30 was significantly higher than that of biliary cytology (78.3% (36/46) vs 52.2% (24/46), P = 0.015). The sensitivity of M30 (cut-off value: 74.429 U/l) was significantly higher than that of biliary cytology and brush cytology (72.4% (21/29) vs 24.1% (7/29), P < 0.001). In conclusion, cell death biomarkers were increased in patients with BTC, and M30 could efficiently diagnose BTC.Mitsuru SugimotoKazumichi AbeManabu HayashiTadayuki TakagiRei SuzukiNaoki KonnoHiroyuki AsamaYuki SatoHiroki IrieKo WatanabeJun NakamuraHitomi KikuchiYuichi WaragaiMika TakasumiMinami HashimotoTakuto HikichiYoshihiro NozawaHiromasa OhiraNature PortfolioarticleCell Death BiomarkersBiliary Tract Cancer (BTC)Biliary CytologyMalignant GroupBenign Biliary Tract DiseaseMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-7 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell Death Biomarkers Biliary Tract Cancer (BTC) Biliary Cytology Malignant Group Benign Biliary Tract Disease Medicine R Science Q
spellingShingle	Cell Death Biomarkers Biliary Tract Cancer (BTC) Biliary Cytology Malignant Group Benign Biliary Tract Disease Medicine R Science Q Mitsuru Sugimoto Kazumichi Abe Manabu Hayashi Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Minami Hashimoto Takuto Hikichi Yoshihiro Nozawa Hiromasa Ohira The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
description	Abstract In this study, we determined the efficacy of the cell death biomarker cytokeratin 18 for diagnosing biliary tract cancer (BTC). We recruited 36 patients with BTC (Malignant group) and 45 patients with benign biliary tract disease (Benign group) for this study. We used M30 and M65 as cell death biomarkers. M30 levels indicate apoptosis, and M65 levels indicate both apoptosis and necrosis. M30 and M65 levels were significantly higher in the Malignant group than in the Benign group (142.4 ± 117.0 vs 48.9 ± 71.2 U/l, P < 0.001; 1513.3 ± 837.4 vs 882.2 ± 831.2 U/l, P = 0.001). The diagnosability of M30 was the highest of the four markers (CEA, CA19-9, M30, M65) (cut-off value: 74.429 U/l, sensitivity: 72.2%, specificity: 77.1%, AUC: 0.771). The sensitivity of M30 (cut-off value: 74.429 U/l) was significantly higher than that of biliary cytology (76% (19/25) vs 12% (3/25), P < 0.001), and the accuracy of M30 was significantly higher than that of biliary cytology (78.3% (36/46) vs 52.2% (24/46), P = 0.015). The sensitivity of M30 (cut-off value: 74.429 U/l) was significantly higher than that of biliary cytology and brush cytology (72.4% (21/29) vs 24.1% (7/29), P < 0.001). In conclusion, cell death biomarkers were increased in patients with BTC, and M30 could efficiently diagnose BTC.
format	article
author	Mitsuru Sugimoto Kazumichi Abe Manabu Hayashi Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Minami Hashimoto Takuto Hikichi Yoshihiro Nozawa Hiromasa Ohira
author_facet	Mitsuru Sugimoto Kazumichi Abe Manabu Hayashi Tadayuki Takagi Rei Suzuki Naoki Konno Hiroyuki Asama Yuki Sato Hiroki Irie Ko Watanabe Jun Nakamura Hitomi Kikuchi Yuichi Waragai Mika Takasumi Minami Hashimoto Takuto Hikichi Yoshihiro Nozawa Hiromasa Ohira
author_sort	Mitsuru Sugimoto
title	The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
title_short	The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
title_full	The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
title_fullStr	The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
title_full_unstemmed	The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
title_sort	efficacy of serum cell death biomarkers for diagnosing biliary tract cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a2bfe63fe304f33a6de52b0dae27cfd
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The efficacy of serum cell death biomarkers for diagnosing biliary tract cancer

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