Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract

The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, com...

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Autores principales:	Yusfiati, W. Manalu, H. Maheshwari, Andryanto
Formato:	article
Lenguaje:	EN
Publicado:	IPB University 2021
Materias:	superoxide dismutase repairing activity uterus tristaniopsis Animal culture SF1-1100
Acceso en línea:	https://doaj.org/article/3a2ddfd2447e497ca9be7cd8e9e4d631
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spelling	oai:doaj.org-article:3a2ddfd2447e497ca9be7cd8e9e4d6312021-11-15T23:17:21ZPhysiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract10.5398/tasj.2021.44.4.4152615-787X2615-790Xhttps://doaj.org/article/3a2ddfd2447e497ca9be7cd8e9e4d6312021-11-01T00:00:00Zhttps://journal.ipb.ac.id/index.php/tasj/article/view/33026https://doaj.org/toc/2615-787Xhttps://doaj.org/toc/2615-790X The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, completely randomized design. Seventy-two female rats were divided into 4 groups, namely, control 1 (P01= 9), control 2 (P02= 9), giving birth once (P1= 27), and giving birth twice (P2= 27). The experimental rats were given treatments orally with 4 doses, namely 0 mg/kg BW, 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Observation data were taken on days 0, 3, and 5 after parturition. Variables measured were SOD activity, MDA levels, and the number of cells in the uterine tissue expressing Cu, Zn SOD. The results of studies on the condition of P01, P02, P1, and P2 showed significant changes in Cu, Zn SOD expressions. The low of SOD and MDA activities were found at doses of 100 mg and 150 mg. The high number of cells expressing Cu, Zn SOD in the epithelium cells and gland cells were found at a dose of 100 mg. Antioxidant plant extracts and their dosages determine the activities of SOD, MDA, and Cu, Zn SOD expressions in the uterus that will affect the process of repairing and involution of uterine tissue. Allegedly, the bioactive compounds extracted at certain doses effectively affect the physiological repair of cells in the uterine tissue of postpartum mothers. YusfiatiW. ManaluH. MaheshwariAndryantoIPB Universityarticlesuperoxide dismutaserepairing activityuterustristaniopsisAnimal cultureSF1-1100ENTropical Animal Science Journal, Vol 44, Iss 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	superoxide dismutase repairing activity uterus tristaniopsis Animal culture SF1-1100
spellingShingle	superoxide dismutase repairing activity uterus tristaniopsis Animal culture SF1-1100 Yusfiati W. Manalu H. Maheshwari Andryanto Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
description	The study examined the effectiveness of ethyl-acetate fraction of Pelawan extract on the activities of superoxide dismutases in physiological repairing of uterus in postpartum rat based on SOD activity, MDA concentration, and Cu, Zn SOD expressions. The experiment was arranged with a factorial, completely randomized design. Seventy-two female rats were divided into 4 groups, namely, control 1 (P01= 9), control 2 (P02= 9), giving birth once (P1= 27), and giving birth twice (P2= 27). The experimental rats were given treatments orally with 4 doses, namely 0 mg/kg BW, 50 mg/kg BW, 100 mg/kg BW, and 150 mg/kg BW. Observation data were taken on days 0, 3, and 5 after parturition. Variables measured were SOD activity, MDA levels, and the number of cells in the uterine tissue expressing Cu, Zn SOD. The results of studies on the condition of P01, P02, P1, and P2 showed significant changes in Cu, Zn SOD expressions. The low of SOD and MDA activities were found at doses of 100 mg and 150 mg. The high number of cells expressing Cu, Zn SOD in the epithelium cells and gland cells were found at a dose of 100 mg. Antioxidant plant extracts and their dosages determine the activities of SOD, MDA, and Cu, Zn SOD expressions in the uterus that will affect the process of repairing and involution of uterine tissue. Allegedly, the bioactive compounds extracted at certain doses effectively affect the physiological repair of cells in the uterine tissue of postpartum mothers.
format	article
author	Yusfiati W. Manalu H. Maheshwari Andryanto
author_facet	Yusfiati W. Manalu H. Maheshwari Andryanto
author_sort	Yusfiati
title	Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
title_short	Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
title_full	Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
title_fullStr	Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
title_full_unstemmed	Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract
title_sort	physiological repairing of postpartum rat uterus treated with pelawan (tristaniopsis obovata benn.) extract
publisher	IPB University
publishDate	2021
url	https://doaj.org/article/3a2ddfd2447e497ca9be7cd8e9e4d631
work_keys_str_mv	AT yusfiati physiologicalrepairingofpostpartumratuterustreatedwithpelawantristaniopsisobovatabennextract AT wmanalu physiologicalrepairingofpostpartumratuterustreatedwithpelawantristaniopsisobovatabennextract AT hmaheshwari physiologicalrepairingofpostpartumratuterustreatedwithpelawantristaniopsisobovatabennextract AT andryanto physiologicalrepairingofpostpartumratuterustreatedwithpelawantristaniopsisobovatabennextract
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Physiological Repairing of Postpartum Rat Uterus Treated with Pelawan (Tristaniopsis obovata Benn.) Extract

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