BLOOD MONOCYTE SUBPOPULATIONS DURING UNCOMPLICATED CORONARY ARTERY BYPASS SURGERY
Abstract. We have observed thirty-six patients with coronary artery disease (CAD) who have undergone coronary artery bypass graft (CABG) surgery. In patients with uncomplicated clinical course post-CABG, total lymphocyte counts, T-, B- and NK-cell contents did not significantly differ from baseline...
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| Main Authors: | , , , , , |
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| Format: | article |
| Language: | RU |
| Published: |
SPb RAACI
2014
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| Subjects: | |
| Online Access: | https://doaj.org/article/3a30144926a74c64a59f933c868cce3b |
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| Summary: | Abstract. We have observed thirty-six patients with coronary artery disease (CAD) who have undergone coronary artery bypass graft (CABG) surgery. In patients with uncomplicated clinical course post-CABG, total lymphocyte counts, T-, B- and NK-cell contents did not significantly differ from baseline levels. Meanwhile, the numbers of CD14HIGH and CD14LOW monocyte subpopulations showed significant differences from initial levels at day 1 and day 7 after surgery. The changes in monocyte subsets in blood of patients with and absence of post-surgical septic complications reflected severity of inflammatory response, and development of systemic inflammatory syndrome. In such a case, further studies of peripheral blood monocytes can be both a useful tool for studying the mechanisms of systemic inflammation, as well as a good diagnostic system, in order to assess the patient’s condition and to predict post-surgical clinical outcomes. |
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