TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin liga...

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Autores principales:	Sayaka Aizawa, Toru Okamoto, Yukari Sugiyama, Takahisa Kouwaki, Ayano Ito, Tatsuya Suzuki, Chikako Ono, Takasuke Fukuhara, Masahiro Yamamoto, Masayasu Okochi, Nobuhiko Hiraga, Michio Imamura, Kazuaki Chayama, Ryosuke Suzuki, Ikuo Shoji, Kohji Moriishi, Kyoji Moriya, Kazuhiko Koike, Yoshiharu Matsuura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a32cdc5f1e44ed986f4b68efe536826
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spelling	oai:doaj.org-article:3a32cdc5f1e44ed986f4b68efe5368262021-12-02T15:34:54ZTRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis10.1038/ncomms113792041-1723https://doaj.org/article/3a32cdc5f1e44ed986f4b68efe5368262016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11379https://doaj.org/toc/2041-1723A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin ligase TRC8.Sayaka AizawaToru OkamotoYukari SugiyamaTakahisa KouwakiAyano ItoTatsuya SuzukiChikako OnoTakasuke FukuharaMasahiro YamamotoMasayasu OkochiNobuhiko HiragaMichio ImamuraKazuaki ChayamaRyosuke SuzukiIkuo ShojiKohji MoriishiKyoji MoriyaKazuhiko KoikeYoshiharu MatsuuraNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sayaka Aizawa Toru Okamoto Yukari Sugiyama Takahisa Kouwaki Ayano Ito Tatsuya Suzuki Chikako Ono Takasuke Fukuhara Masahiro Yamamoto Masayasu Okochi Nobuhiko Hiraga Michio Imamura Kazuaki Chayama Ryosuke Suzuki Ikuo Shoji Kohji Moriishi Kyoji Moriya Kazuhiko Koike Yoshiharu Matsuura TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
description	A cellular protease, SPP, participates in production of the mature core protein of hepatitis C virus (HCV). Here, the authors show in mouse models that SPP inhibition reduces viral propagation and pathogenesis via proteasomal degradation of the immature core protein mediated by the E3 ubiquitin ligase TRC8.
format	article
author	Sayaka Aizawa Toru Okamoto Yukari Sugiyama Takahisa Kouwaki Ayano Ito Tatsuya Suzuki Chikako Ono Takasuke Fukuhara Masahiro Yamamoto Masayasu Okochi Nobuhiko Hiraga Michio Imamura Kazuaki Chayama Ryosuke Suzuki Ikuo Shoji Kohji Moriishi Kyoji Moriya Kazuhiko Koike Yoshiharu Matsuura
author_facet	Sayaka Aizawa Toru Okamoto Yukari Sugiyama Takahisa Kouwaki Ayano Ito Tatsuya Suzuki Chikako Ono Takasuke Fukuhara Masahiro Yamamoto Masayasu Okochi Nobuhiko Hiraga Michio Imamura Kazuaki Chayama Ryosuke Suzuki Ikuo Shoji Kohji Moriishi Kyoji Moriya Kazuhiko Koike Yoshiharu Matsuura
author_sort	Sayaka Aizawa
title	TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
title_short	TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
title_full	TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
title_fullStr	TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
title_full_unstemmed	TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis
title_sort	trc8-dependent degradation of hepatitis c virus immature core protein regulates viral propagation and pathogenesis
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3a32cdc5f1e44ed986f4b68efe536826
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TRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis

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