Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction

Abstract The balance between activities of fear neurons and extinction neurons in the basolateral nucleus of the basal amygdala (BAL) has been hypothesized to encode fear states after extinction. However, it remains unclear whether these neurons are solely responsible for encoding fear states. In th...

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Autores principales:	Junghwa Lee, Bobae An, Sukwoo Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a362914a1ae46b190d038706dfddc35
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spelling	oai:doaj.org-article:3a362914a1ae46b190d038706dfddc352021-12-02T15:00:25ZLongitudinal recordings of single units in the basal amygdala during fear conditioning and extinction10.1038/s41598-021-90530-x2045-2322https://doaj.org/article/3a362914a1ae46b190d038706dfddc352021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90530-xhttps://doaj.org/toc/2045-2322Abstract The balance between activities of fear neurons and extinction neurons in the basolateral nucleus of the basal amygdala (BAL) has been hypothesized to encode fear states after extinction. However, it remains unclear whether these neurons are solely responsible for encoding fear states. In this study, we stably recorded single-unit activities in the BAL during fear conditioning and extinction for 3 days, providing a comprehensive view on how different BAL neurons respond during fear learning. We found BAL neurons that showed excitatory responses to the conditioned stimulus (CS) after fear conditioning (‘conditioning-potentiated neurons’) and another population that showed excitatory responses to the CS after extinction (‘extinction-potentiated neurons’). Interestingly, we also found BAL neurons that developed inhibitory responses to the CS after fear conditioning (‘conditioning-inhibited neurons’) or after extinction (‘extinction-inhibited neurons’). BAL neurons that showed excitatory responses to the CS displayed various functional connectivity with each other, whereas less connectivity was observed among neurons with inhibitory responses to the CS. Intriguingly, we found correlative neuronal activities between conditioning-potentiated neurons and neurons with inhibitory responses to the CS. Our findings suggest that distinct BAL neurons, which are responsive to the CS with excitation or inhibition, encode various facets of fear conditioning and extinction.Junghwa LeeBobae AnSukwoo ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junghwa Lee Bobae An Sukwoo Choi Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
description	Abstract The balance between activities of fear neurons and extinction neurons in the basolateral nucleus of the basal amygdala (BAL) has been hypothesized to encode fear states after extinction. However, it remains unclear whether these neurons are solely responsible for encoding fear states. In this study, we stably recorded single-unit activities in the BAL during fear conditioning and extinction for 3 days, providing a comprehensive view on how different BAL neurons respond during fear learning. We found BAL neurons that showed excitatory responses to the conditioned stimulus (CS) after fear conditioning (‘conditioning-potentiated neurons’) and another population that showed excitatory responses to the CS after extinction (‘extinction-potentiated neurons’). Interestingly, we also found BAL neurons that developed inhibitory responses to the CS after fear conditioning (‘conditioning-inhibited neurons’) or after extinction (‘extinction-inhibited neurons’). BAL neurons that showed excitatory responses to the CS displayed various functional connectivity with each other, whereas less connectivity was observed among neurons with inhibitory responses to the CS. Intriguingly, we found correlative neuronal activities between conditioning-potentiated neurons and neurons with inhibitory responses to the CS. Our findings suggest that distinct BAL neurons, which are responsive to the CS with excitation or inhibition, encode various facets of fear conditioning and extinction.
format	article
author	Junghwa Lee Bobae An Sukwoo Choi
author_facet	Junghwa Lee Bobae An Sukwoo Choi
author_sort	Junghwa Lee
title	Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
title_short	Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
title_full	Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
title_fullStr	Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
title_full_unstemmed	Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
title_sort	longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a362914a1ae46b190d038706dfddc35
work_keys_str_mv	AT junghwalee longitudinalrecordingsofsingleunitsinthebasalamygdaladuringfearconditioningandextinction AT bobaean longitudinalrecordingsofsingleunitsinthebasalamygdaladuringfearconditioningandextinction AT sukwoochoi longitudinalrecordingsofsingleunitsinthebasalamygdaladuringfearconditioningandextinction
_version_	1718389132033523712

Longitudinal recordings of single units in the basal amygdala during fear conditioning and extinction

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