TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY

Increased incidence of malignancies requires a search for new therapeutic approaches. E.g., photodynamic therapy (PDT) is an effective anti-cancer treatment that involves administration of a photosensitizing dye followed by visible light irradiation of the tumor. Pre-clinical studies have shown that...

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Autores principales:	Yu. N. Anokhin, E. V. Abakushina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	photodynamic therapy cancer antitumor immune response natural killer cells mica nkg2d molecules lymphocyte activation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3a36ed1f33f4446a99b18f843de71d47
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spelling	oai:doaj.org-article:3a36ed1f33f4446a99b18f843de71d472021-11-18T08:03:45ZTUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY1563-06252313-741X10.15789/1563-0625-2016-5-405-416https://doaj.org/article/3a36ed1f33f4446a99b18f843de71d472016-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1063https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIncreased incidence of malignancies requires a search for new therapeutic approaches. E.g., photodynamic therapy (PDT) is an effective anti-cancer treatment that involves administration of a photosensitizing dye followed by visible light irradiation of the tumor. Pre-clinical studies have shown that local photodynamic therapy enhances systemic antitumor immunity. Moreover, it is well known that the long-term effects of PDT depend on functioning of intact adaptive immune response. In this context, the immune system plays a fundamental role. Interestingly, the PDT action is associated with stimulation of systemic immune response against a locally treated tumor. In fact, PDT has been shown to effectively stimulate both innate and adaptive immune systems of the host, by triggering the release of various pro-inflammatory and acutephase response mediators thus leading to massive infiltration of the treated site with neutrophils, dendritic cells and other inflammatory cells. PDT efficacy depends, in part, on induction of tumor-specific immune response which is dependent on cytotoxic T lymphocytes and natural killer (NK) cells. The set of specific receptors enables NK cells to recognize surface molecules on the target cells. Expression of the latter molecules is indicative of viral infection, tumor formation, or cell stress (e.g., DNA damage). The NK cells are also involved into various biological processes in the organism, playing a critical role in immune surveillance, thus representing a potential tool for cancer therapy. It was shown that the tumor cells have increased sensitivity to NK cell-mediated lytic action following PDT. In this review, we further discuss potential relationships between PDT and antitumor immune response.Yu. N. AnokhinE. V. AbakushinaSPb RAACIarticlephotodynamic therapycancerantitumor immune responsenatural killer cellsmicankg2d moleculeslymphocyte activationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 5, Pp 405-416 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	photodynamic therapy cancer antitumor immune response natural killer cells mica nkg2d molecules lymphocyte activation Immunologic diseases. Allergy RC581-607
spellingShingle	photodynamic therapy cancer antitumor immune response natural killer cells mica nkg2d molecules lymphocyte activation Immunologic diseases. Allergy RC581-607 Yu. N. Anokhin E. V. Abakushina TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
description	Increased incidence of malignancies requires a search for new therapeutic approaches. E.g., photodynamic therapy (PDT) is an effective anti-cancer treatment that involves administration of a photosensitizing dye followed by visible light irradiation of the tumor. Pre-clinical studies have shown that local photodynamic therapy enhances systemic antitumor immunity. Moreover, it is well known that the long-term effects of PDT depend on functioning of intact adaptive immune response. In this context, the immune system plays a fundamental role. Interestingly, the PDT action is associated with stimulation of systemic immune response against a locally treated tumor. In fact, PDT has been shown to effectively stimulate both innate and adaptive immune systems of the host, by triggering the release of various pro-inflammatory and acutephase response mediators thus leading to massive infiltration of the treated site with neutrophils, dendritic cells and other inflammatory cells. PDT efficacy depends, in part, on induction of tumor-specific immune response which is dependent on cytotoxic T lymphocytes and natural killer (NK) cells. The set of specific receptors enables NK cells to recognize surface molecules on the target cells. Expression of the latter molecules is indicative of viral infection, tumor formation, or cell stress (e.g., DNA damage). The NK cells are also involved into various biological processes in the organism, playing a critical role in immune surveillance, thus representing a potential tool for cancer therapy. It was shown that the tumor cells have increased sensitivity to NK cell-mediated lytic action following PDT. In this review, we further discuss potential relationships between PDT and antitumor immune response.
format	article
author	Yu. N. Anokhin E. V. Abakushina
author_facet	Yu. N. Anokhin E. V. Abakushina
author_sort	Yu. N. Anokhin
title	TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
title_short	TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
title_full	TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
title_fullStr	TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
title_full_unstemmed	TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY
title_sort	tumor-specific immune response after photodynamic therapy
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/3a36ed1f33f4446a99b18f843de71d47
work_keys_str_mv	AT yunanokhin tumorspecificimmuneresponseafterphotodynamictherapy AT evabakushina tumorspecificimmuneresponseafterphotodynamictherapy
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TUMOR-SPECIFIC IMMUNE RESPONSE AFTER PHOTODYNAMIC THERAPY

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