Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma

Osteosarcoma is a malignant tumor that originates in the bones with the characteristics of high malignancy, predisposition to metastasis, and poor prognosis. RNA binding proteins (RBPs) are closely related to various tumors, but their relationship with osteosarcoma remains unclear. Based on GTEx and...

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Autores principales:	Jian Zhang, Xinxin Miao, Tianlong Wu, Jingyu Jia, Xigao Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	RNA-binding protein osteosarcoma prognostic signature overall survival nomogram Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3a38899b98d54e35915d3dd3eb2fb283
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spelling	oai:doaj.org-article:3a38899b98d54e35915d3dd3eb2fb2832021-12-01T23:11:35ZDevelopment and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma2296-889X10.3389/fmolb.2021.751842https://doaj.org/article/3a38899b98d54e35915d3dd3eb2fb2832021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmolb.2021.751842/fullhttps://doaj.org/toc/2296-889XOsteosarcoma is a malignant tumor that originates in the bones with the characteristics of high malignancy, predisposition to metastasis, and poor prognosis. RNA binding proteins (RBPs) are closely related to various tumors, but their relationship with osteosarcoma remains unclear. Based on GTEx and TARGET RNA sequencing data, we applied differential analysis to obtain RBP genes that are differentially expressed in osteosarcoma, and analyzed the functions of these RBPs. After applying univariate and LASSO Cox regression analysis, 10 key prognostic RBPs (TDRD6, TLR8, NXT2, EIF4E3, RPS27L, CPEB3, RBM34, TERT, RPS29, and ZC3HAV1) were screened, and an RBP prognostic risk assessment model for patients with osteosarcoma was established. The independent cohort GSE21257 was used for external verification, and the results showed that the signature has an excellent ability to predict prognosis. In addition, a nomogram that can be used for clinical evaluation was constructed. Finally, the expression levels of 10 prognostic RBPs in osteosarcoma cells and tissues were confirmed through experiments. Our study identified a ten-gene prognostic marker related to RBP, which is of great significance for adjusting the treatment strategy of patients with osteosarcoma and exploring prognostic markers.Jian ZhangJian ZhangXinxin MiaoXinxin MiaoTianlong WuTianlong WuJingyu JiaXigao ChengXigao ChengXigao ChengFrontiers Media S.A.articleRNA-binding proteinosteosarcomaprognostic signatureoverall survivalnomogramBiology (General)QH301-705.5ENFrontiers in Molecular Biosciences, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA-binding protein osteosarcoma prognostic signature overall survival nomogram Biology (General) QH301-705.5
spellingShingle	RNA-binding protein osteosarcoma prognostic signature overall survival nomogram Biology (General) QH301-705.5 Jian Zhang Jian Zhang Xinxin Miao Xinxin Miao Tianlong Wu Tianlong Wu Jingyu Jia Xigao Cheng Xigao Cheng Xigao Cheng Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
description	Osteosarcoma is a malignant tumor that originates in the bones with the characteristics of high malignancy, predisposition to metastasis, and poor prognosis. RNA binding proteins (RBPs) are closely related to various tumors, but their relationship with osteosarcoma remains unclear. Based on GTEx and TARGET RNA sequencing data, we applied differential analysis to obtain RBP genes that are differentially expressed in osteosarcoma, and analyzed the functions of these RBPs. After applying univariate and LASSO Cox regression analysis, 10 key prognostic RBPs (TDRD6, TLR8, NXT2, EIF4E3, RPS27L, CPEB3, RBM34, TERT, RPS29, and ZC3HAV1) were screened, and an RBP prognostic risk assessment model for patients with osteosarcoma was established. The independent cohort GSE21257 was used for external verification, and the results showed that the signature has an excellent ability to predict prognosis. In addition, a nomogram that can be used for clinical evaluation was constructed. Finally, the expression levels of 10 prognostic RBPs in osteosarcoma cells and tissues were confirmed through experiments. Our study identified a ten-gene prognostic marker related to RBP, which is of great significance for adjusting the treatment strategy of patients with osteosarcoma and exploring prognostic markers.
format	article
author	Jian Zhang Jian Zhang Xinxin Miao Xinxin Miao Tianlong Wu Tianlong Wu Jingyu Jia Xigao Cheng Xigao Cheng Xigao Cheng
author_facet	Jian Zhang Jian Zhang Xinxin Miao Xinxin Miao Tianlong Wu Tianlong Wu Jingyu Jia Xigao Cheng Xigao Cheng Xigao Cheng
author_sort	Jian Zhang
title	Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
title_short	Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
title_full	Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
title_fullStr	Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
title_full_unstemmed	Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma
title_sort	development and validation of ten-rna binding protein signature predicts overall survival in osteosarcoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3a38899b98d54e35915d3dd3eb2fb283
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Development and Validation of Ten-RNA Binding Protein Signature Predicts Overall Survival in Osteosarcoma

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