A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy

Malaria transmission is effected by intra-erythrocytic parasites that commit to sexual development and form gametocytes. Here, the authors show that early reticulocytes in the major sites of haematopoiesis establish a cryptic asexual cycle; this cycle is characterised by early preferential commitmen...

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Autores principales:	Rebecca S. Lee, Andrew P. Waters, James M. Brewer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a394ccac7a34884be1fb342aacb5e2b
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spelling	oai:doaj.org-article:3a394ccac7a34884be1fb342aacb5e2b2021-12-02T16:49:18ZA cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy10.1038/s41467-018-04108-92041-1723https://doaj.org/article/3a394ccac7a34884be1fb342aacb5e2b2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04108-9https://doaj.org/toc/2041-1723Malaria transmission is effected by intra-erythrocytic parasites that commit to sexual development and form gametocytes. Here, the authors show that early reticulocytes in the major sites of haematopoiesis establish a cryptic asexual cycle; this cycle is characterised by early preferential commitment to gametocytogenesis, which initiates malaria transmission and drug resistance.Rebecca S. LeeAndrew P. WatersJames M. BrewerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rebecca S. Lee Andrew P. Waters James M. Brewer A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
description	Malaria transmission is effected by intra-erythrocytic parasites that commit to sexual development and form gametocytes. Here, the authors show that early reticulocytes in the major sites of haematopoiesis establish a cryptic asexual cycle; this cycle is characterised by early preferential commitment to gametocytogenesis, which initiates malaria transmission and drug resistance.
format	article
author	Rebecca S. Lee Andrew P. Waters James M. Brewer
author_facet	Rebecca S. Lee Andrew P. Waters James M. Brewer
author_sort	Rebecca S. Lee
title	A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
title_short	A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
title_full	A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
title_fullStr	A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
title_full_unstemmed	A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
title_sort	cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a394ccac7a34884be1fb342aacb5e2b
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A cryptic cycle in haematopoietic niches promotes initiation of malaria transmission and evasion of chemotherapy

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