A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic

ABSTRACT Mass drug administration (MDA) programs have achieved remarkable success in limiting the pathology and transmission of the human parasitic infections onchocerciasis and lymphatic filariasis. The full implementation of MDA campaigns for filariasis elimination has been stymied by the unaccept...

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Autor principal:	Timothy G. Geary
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/3a3aee91ccfc4486b0edb2f3326721f1
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spelling	oai:doaj.org-article:3a3aee91ccfc4486b0edb2f3326721f12021-11-15T15:41:42ZA Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic10.1128/mBio.00456-162150-7511https://doaj.org/article/3a3aee91ccfc4486b0edb2f3326721f12016-05-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00456-16https://doaj.org/toc/2150-7511ABSTRACT Mass drug administration (MDA) programs have achieved remarkable success in limiting the pathology and transmission of the human parasitic infections onchocerciasis and lymphatic filariasis. The full implementation of MDA campaigns for filariasis elimination has been stymied by the unacceptable incidence of severe adverse events observed following drug treatment of a subset of individuals who harbor high loads of Loa loa microfilaria. Extending MDA strategies to regions where loiasis is coendemic could be done confidently if a simple, inexpensive, and rapid diagnostic method was available that could accurately identify individuals who have L. loa microfilarial loads above the risk threshold and could thus be excluded from treatment. A recent paper in mBio reports the discovery of an antigen unique to L. loa microfilaria that can be detected in blood and urine and may form the basis for such an assay. Further work will reveal whether this discovery will smooth the path to achieve filariasis eradication.Timothy G. GearyAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 2 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Timothy G. Geary A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
description	ABSTRACT Mass drug administration (MDA) programs have achieved remarkable success in limiting the pathology and transmission of the human parasitic infections onchocerciasis and lymphatic filariasis. The full implementation of MDA campaigns for filariasis elimination has been stymied by the unacceptable incidence of severe adverse events observed following drug treatment of a subset of individuals who harbor high loads of Loa loa microfilaria. Extending MDA strategies to regions where loiasis is coendemic could be done confidently if a simple, inexpensive, and rapid diagnostic method was available that could accurately identify individuals who have L. loa microfilarial loads above the risk threshold and could thus be excluded from treatment. A recent paper in mBio reports the discovery of an antigen unique to L. loa microfilaria that can be detected in blood and urine and may form the basis for such an assay. Further work will reveal whether this discovery will smooth the path to achieve filariasis eradication.
format	article
author	Timothy G. Geary
author_facet	Timothy G. Geary
author_sort	Timothy G. Geary
title	A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
title_short	A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
title_full	A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
title_fullStr	A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
title_full_unstemmed	A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic
title_sort	step toward eradication of human filariases in areas where <italic toggle="yes">loa</italic> is endemic
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/3a3aee91ccfc4486b0edb2f3326721f1
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A Step Toward Eradication of Human Filariases in Areas Where <italic toggle="yes">Loa</italic> Is Endemic

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