Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastro...

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Autores principales:	Zhao Hengfang, Zhang Xiaoyan, Zhang Bojing, Qu Xiaoyuan
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	antioxidant anti-inflammatory gastric injury myeloperoxidase nitric oxide Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3a3bb0ac14984957ae385ff673875529
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spelling	oai:doaj.org-article:3a3bb0ac14984957ae385ff6738755292021-12-05T14:10:41ZGastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities2391-541210.1515/biol-2021-0075https://doaj.org/article/3a3bb0ac14984957ae385ff6738755292021-07-01T00:00:00Zhttps://doi.org/10.1515/biol-2021-0075https://doaj.org/toc/2391-5412Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastroprotective role of diosgenin on gastric mucosal damage caused by HCl/ethanol in rats. Male Sprague-Dawley rats were intragastrically administered with diosgenin (20 mg/kg) before HCl/ethanol (0.15 M HCl in 98 % ethanol) administration. Omeprazole was used as a positive control. Diosgenin-attenuated oxidative stress by enhancing (p < 0.05) antioxidant enzymes, reducing lipid peroxidation (MDA), and modulating nitric oxide (NO) levels. Anti-inflammatory effects of diosgenin were observed by a reduction in pro-inflammatory cytokines (p < 0.05), decreased myeloperoxidase (MPO) activities (p < 0.05), and histopathological observation of gastric mucosal damage. Western blot analysis provided evidence on the downregulation of NF-κβ by diosgenin. The findings showed that diosgenin has a significant protective role on gastric injury caused by HCl/ethanol, through its antioxidant, anti-inflammatory role, and suppression of NF-κβ and MPO activities.Zhao HengfangZhang XiaoyanZhang BojingQu XiaoyuanDe Gruyterarticleantioxidantanti-inflammatorygastric injurymyeloperoxidasenitric oxideBiology (General)QH301-705.5ENOpen Life Sciences, Vol 16, Iss 1, Pp 719-727 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antioxidant anti-inflammatory gastric injury myeloperoxidase nitric oxide Biology (General) QH301-705.5
spellingShingle	antioxidant anti-inflammatory gastric injury myeloperoxidase nitric oxide Biology (General) QH301-705.5 Zhao Hengfang Zhang Xiaoyan Zhang Bojing Qu Xiaoyuan Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
description	Gastric mucosal injury is caused by an imbalance between the mucosal defense and gastro-irritants, leading to gastroenteritis. Diosgenin is a steroidal sapogenin found in the wild Yam plant that has been reported with several pharmacological properties. The aim of this study is to explore the gastroprotective role of diosgenin on gastric mucosal damage caused by HCl/ethanol in rats. Male Sprague-Dawley rats were intragastrically administered with diosgenin (20 mg/kg) before HCl/ethanol (0.15 M HCl in 98 % ethanol) administration. Omeprazole was used as a positive control. Diosgenin-attenuated oxidative stress by enhancing (p < 0.05) antioxidant enzymes, reducing lipid peroxidation (MDA), and modulating nitric oxide (NO) levels. Anti-inflammatory effects of diosgenin were observed by a reduction in pro-inflammatory cytokines (p < 0.05), decreased myeloperoxidase (MPO) activities (p < 0.05), and histopathological observation of gastric mucosal damage. Western blot analysis provided evidence on the downregulation of NF-κβ by diosgenin. The findings showed that diosgenin has a significant protective role on gastric injury caused by HCl/ethanol, through its antioxidant, anti-inflammatory role, and suppression of NF-κβ and MPO activities.
format	article
author	Zhao Hengfang Zhang Xiaoyan Zhang Bojing Qu Xiaoyuan
author_facet	Zhao Hengfang Zhang Xiaoyan Zhang Bojing Qu Xiaoyuan
author_sort	Zhao Hengfang
title	Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
title_short	Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
title_full	Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
title_fullStr	Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
title_full_unstemmed	Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities
title_sort	gastroprotective effects of diosgenin against hcl/ethanol-induced gastric mucosal injury through suppression of nf-κβ and myeloperoxidase activities
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/3a3bb0ac14984957ae385ff673875529
work_keys_str_mv	AT zhaohengfang gastroprotectiveeffectsofdiosgeninagainsthclethanolinducedgastricmucosalinjurythroughsuppressionofnfkbandmyeloperoxidaseactivities AT zhangxiaoyan gastroprotectiveeffectsofdiosgeninagainsthclethanolinducedgastricmucosalinjurythroughsuppressionofnfkbandmyeloperoxidaseactivities AT zhangbojing gastroprotectiveeffectsofdiosgeninagainsthclethanolinducedgastricmucosalinjurythroughsuppressionofnfkbandmyeloperoxidaseactivities AT quxiaoyuan gastroprotectiveeffectsofdiosgeninagainsthclethanolinducedgastricmucosalinjurythroughsuppressionofnfkbandmyeloperoxidaseactivities
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Gastroprotective effects of diosgenin against HCl/ethanol-induced gastric mucosal injury through suppression of NF-κβ and myeloperoxidase activities

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