Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

Zeyong Li,1,* Yuee Cai,2,* Yiqiao Zhao,1 Hua Yu,2 Haiyu Zhou,3 Meiwan Chen2 1Department of Laboratory Medicine, Guangdong No 2 Provincial People’s Hospital, Guangzhou, China; 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University o...

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Autores principales:	Li ZY, Cai Y, Zhao YQ, Yu H, Zhou HY, Chen MW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	mitoxantrone polymeric mixed micelles multidrug resistance photodynamic therapy breast cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a3cdf58ade14775863b1ce7d463b929
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spelling	oai:doaj.org-article:3a3cdf58ade14775863b1ce7d463b9292021-12-02T01:04:04ZPolymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy1178-2013https://doaj.org/article/3a3cdf58ade14775863b1ce7d463b9292017-09-01T00:00:00Zhttps://www.dovepress.com/polymeric-mixed-micelles-loaded-mitoxantrone-for-overcoming-multidrug--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zeyong Li,1,* Yuee Cai,2,* Yiqiao Zhao,1 Hua Yu,2 Haiyu Zhou,3 Meiwan Chen2 1Department of Laboratory Medicine, Guangdong No 2 Provincial People’s Hospital, Guangzhou, China; 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; 3Department of Thoracic Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, South China University of Technology, Guangzhou, China *These authors contributed equally to this work Abstract: Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(D,L-lactide-co-glycolide)–poly(ethylene glycol)–poly(D,L-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light. MIT-PFP/PPP mixed micelles showed effective interaction with near-infrared light at the wavelength of 660 nm and exerted great cytotoxicity in MCF-7/ADR cells with irradiation. Furthermore, MIT-PFP/PPP mixed micelles could improve reactive oxygen species (ROS) levels, decrease P-glycoprotein activity, and increase the cellular uptake of drugs with improved intracellular drug concentrations, which induced cell apoptosis in MCF-7/ADR cells under irradiation, despite MDR effect, as indicated by the increased level of cleaved poly ADP-ribose polymerase. These findings suggested that MIT-PFP/PPP mixed micelles may become a promising strategy to effectively reverse the MDR effect via photodynamic therapy in breast cancer. Keywords: mitoxantrone, polymeric mixed micelles, multidrug resistance, photodynamic therapy, breast cancerLi ZYCai YZhao YQYu HZhou HYChen MWDove Medical Pressarticlemitoxantronepolymeric mixed micellesmultidrug resistancephotodynamic therapybreast cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 12, Pp 6595-6604 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	mitoxantrone polymeric mixed micelles multidrug resistance photodynamic therapy breast cancer Medicine (General) R5-920
spellingShingle	mitoxantrone polymeric mixed micelles multidrug resistance photodynamic therapy breast cancer Medicine (General) R5-920 Li ZY Cai Y Zhao YQ Yu H Zhou HY Chen MW Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
description	Zeyong Li,1,* Yuee Cai,2,* Yiqiao Zhao,1 Hua Yu,2 Haiyu Zhou,3 Meiwan Chen2 1Department of Laboratory Medicine, Guangdong No 2 Provincial People’s Hospital, Guangzhou, China; 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; 3Department of Thoracic Surgery, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, South China University of Technology, Guangzhou, China *These authors contributed equally to this work Abstract: Mitoxantrone (MIT) is an anticancer agent with photosensitive properties that is commonly used in various cancers. Multidrug resistance (MDR) effect has been an obstacle to using MIT for cancer therapy. Photochemical internalization, on account of photodynamic therapy, has been applied to improve the therapeutic effect of cancers with MDR effect. In this study, an MIT-poly(ε-caprolactone)-pluronic F68-poly(ε-caprolactone)/poly(D,L-lactide-co-glycolide)–poly(ethylene glycol)–poly(D,L-lactide-co-glycolide) (MIT-PFP/PPP) mixed micelles system was applied to reverse the effect of MDR in MCF-7/ADR cells via photochemical reaction when exposed to near-infrared light. MIT-PFP/PPP mixed micelles showed effective interaction with near-infrared light at the wavelength of 660 nm and exerted great cytotoxicity in MCF-7/ADR cells with irradiation. Furthermore, MIT-PFP/PPP mixed micelles could improve reactive oxygen species (ROS) levels, decrease P-glycoprotein activity, and increase the cellular uptake of drugs with improved intracellular drug concentrations, which induced cell apoptosis in MCF-7/ADR cells under irradiation, despite MDR effect, as indicated by the increased level of cleaved poly ADP-ribose polymerase. These findings suggested that MIT-PFP/PPP mixed micelles may become a promising strategy to effectively reverse the MDR effect via photodynamic therapy in breast cancer. Keywords: mitoxantrone, polymeric mixed micelles, multidrug resistance, photodynamic therapy, breast cancer
format	article
author	Li ZY Cai Y Zhao YQ Yu H Zhou HY Chen MW
author_facet	Li ZY Cai Y Zhao YQ Yu H Zhou HY Chen MW
author_sort	Li ZY
title	Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
title_short	Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
title_full	Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
title_fullStr	Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
title_full_unstemmed	Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
title_sort	polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3a3cdf58ade14775863b1ce7d463b929
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_version_	1718403309415432192

Polymeric mixed micelles loaded mitoxantrone for overcoming multidrug resistance in breast cancer via photodynamic therapy

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