Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy

Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by...

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Autores principales:	Hui Du, Ozioma Udochukwu Akakuru, Chenyang Yao, Fang Yang, Aiguo Wu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Magnetic nanomaterials Transition metals Dopant Bioimaging Cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3a3e48029f8f45568aad939dce31a18a
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spelling	oai:doaj.org-article:3a3e48029f8f45568aad939dce31a18a2021-11-14T04:31:38ZTransition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy1936-523310.1016/j.tranon.2021.101264https://doaj.org/article/3a3e48029f8f45568aad939dce31a18a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1936523321002552https://doaj.org/toc/1936-5233Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by several parameters (e.g., particle size, shape, composition, core-shell structure, etc.), among which the amount of transition metal doping plays an important factor. For this reason, the doping of ferrite with transition metals has been used as an effective strategy to precisely tailor MNPs to achieve satisfactory performance in biomedical applications. In this review, we first introduced the main properties of coordinated MNPs (including magnetic moment and saturated magnetisation) and provide a comprehensive overview of the mechanistic studies related to the doping of transition metal ions into ferrite to precisely modulate its magnetic properties. We also highlighted the potential mechanisms and recent advances in transition metal ion-doped MNPs (TMNPs) for bioimaging (magnetic resonance imaging and magnetic particle imaging) and tumour therapy (e.g., magneto-mechanical killing, magnetothermal therapy, and drug delivery). Finally, we summarised the current challenges and future trends of TMNPs in the biomedical field based on the latest advances by researchers.Hui DuOzioma Udochukwu AkakuruChenyang YaoFang YangAiguo WuElsevierarticleMagnetic nanomaterialsTransition metalsDopantBioimagingCancer therapyNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENTranslational Oncology, Vol 15, Iss 1, Pp 101264- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Magnetic nanomaterials Transition metals Dopant Bioimaging Cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Magnetic nanomaterials Transition metals Dopant Bioimaging Cancer therapy Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Hui Du Ozioma Udochukwu Akakuru Chenyang Yao Fang Yang Aiguo Wu Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
description	Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by several parameters (e.g., particle size, shape, composition, core-shell structure, etc.), among which the amount of transition metal doping plays an important factor. For this reason, the doping of ferrite with transition metals has been used as an effective strategy to precisely tailor MNPs to achieve satisfactory performance in biomedical applications. In this review, we first introduced the main properties of coordinated MNPs (including magnetic moment and saturated magnetisation) and provide a comprehensive overview of the mechanistic studies related to the doping of transition metal ions into ferrite to precisely modulate its magnetic properties. We also highlighted the potential mechanisms and recent advances in transition metal ion-doped MNPs (TMNPs) for bioimaging (magnetic resonance imaging and magnetic particle imaging) and tumour therapy (e.g., magneto-mechanical killing, magnetothermal therapy, and drug delivery). Finally, we summarised the current challenges and future trends of TMNPs in the biomedical field based on the latest advances by researchers.
format	article
author	Hui Du Ozioma Udochukwu Akakuru Chenyang Yao Fang Yang Aiguo Wu
author_facet	Hui Du Ozioma Udochukwu Akakuru Chenyang Yao Fang Yang Aiguo Wu
author_sort	Hui Du
title	Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
title_short	Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
title_full	Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
title_fullStr	Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
title_full_unstemmed	Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
title_sort	transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/3a3e48029f8f45568aad939dce31a18a
work_keys_str_mv	AT huidu transitionmetaliondopedferritesnanoparticlesforbioimagingandcancertherapy AT oziomaudochukwuakakuru transitionmetaliondopedferritesnanoparticlesforbioimagingandcancertherapy AT chenyangyao transitionmetaliondopedferritesnanoparticlesforbioimagingandcancertherapy AT fangyang transitionmetaliondopedferritesnanoparticlesforbioimagingandcancertherapy AT aiguowu transitionmetaliondopedferritesnanoparticlesforbioimagingandcancertherapy
_version_	1718429950763073536

Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy

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