Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic insights into Piezo-mediated mechanotransduction.

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Autores principales:	Jerome J. Lacroix, Wesley M. Botello-Smith, Yun Luo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a4609bc5a3f476f90902b6c75f467b5
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spelling	oai:doaj.org-article:3a4609bc5a3f476f90902b6c75f467b52021-12-02T16:49:34ZProbing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda110.1038/s41467-018-04405-32041-1723https://doaj.org/article/3a4609bc5a3f476f90902b6c75f467b52018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04405-3https://doaj.org/toc/2041-1723Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic insights into Piezo-mediated mechanotransduction.Jerome J. LacroixWesley M. Botello-SmithYun LuoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jerome J. Lacroix Wesley M. Botello-Smith Yun Luo Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
description	Piezo ion channels transduce mechanical stimuli into biological signals but the underlying mechanism has remained elusive. Here, the authors use the selective agonist Yoda1 to identify molecular determinants of Piezo activation, providing mechanistic insights into Piezo-mediated mechanotransduction.
format	article
author	Jerome J. Lacroix Wesley M. Botello-Smith Yun Luo
author_facet	Jerome J. Lacroix Wesley M. Botello-Smith Yun Luo
author_sort	Jerome J. Lacroix
title	Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
title_short	Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
title_full	Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
title_fullStr	Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
title_full_unstemmed	Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1
title_sort	probing the gating mechanism of the mechanosensitive channel piezo1 with the small molecule yoda1
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a4609bc5a3f476f90902b6c75f467b5
work_keys_str_mv	AT jeromejlacroix probingthegatingmechanismofthemechanosensitivechannelpiezo1withthesmallmoleculeyoda1 AT wesleymbotellosmith probingthegatingmechanismofthemechanosensitivechannelpiezo1withthesmallmoleculeyoda1 AT yunluo probingthegatingmechanismofthemechanosensitivechannelpiezo1withthesmallmoleculeyoda1
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Probing the gating mechanism of the mechanosensitive channel Piezo1 with the small molecule Yoda1

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