Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia

Background. Acute postoperative pain (APP) has a high incidence in breast surgery, and opioids are the most commonly used drugs for its management; however, they are not free from systemic side effects, which may increase comorbidity. In the past few years, opioid-free anaesthesia has been favoured...

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Autores principales:	Mirian López, María Luz Padilla, Blas García, Javier Orozco, Ana María Rodilla
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a464b35691e401d9c14eeec13b45e27
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spelling	oai:doaj.org-article:3a464b35691e401d9c14eeec13b45e272021-11-29T00:55:57ZPrevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia1918-152310.1155/2021/3290289https://doaj.org/article/3a464b35691e401d9c14eeec13b45e272021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3290289https://doaj.org/toc/1918-1523Background. Acute postoperative pain (APP) has a high incidence in breast surgery, and opioids are the most commonly used drugs for its management; however, they are not free from systemic side effects, which may increase comorbidity. In the past few years, opioid-free anaesthesia has been favoured with promising results. Methods. We conducted a descriptive study including 71 patients who underwent breast cancer surgery. The opioid group (n = 41) received fentanyl for induction, remifentanil for maintenance, and rescue morphine before waking up, whereas the ketamine group (n = 30) received a ketamine bolus for induction followed by continuous ketamine infusion during surgery. Later, the presence and intensity of pain were registered, using the Numeric Rating Scale (NRS 1–10) for pain, at different times in the recovery room, at 24 hours and at 3 months. Results. Administration of ketamine is more effective than opioid use for APP prevention in breast cancer surgery because the ketamine group presented with less pain than the opioid group (p < 0.05) at all measured times. When there was pain, patients in the ketamine group gave a lower score to its intensity (p < 0.05). Conclusions. Ketamine could reduce the incidence of APP in breast cancer surgery, compared to opioids.Mirian LópezMaría Luz PadillaBlas GarcíaJavier OrozcoAna María RodillaHindawi LimitedarticleMedicine (General)R5-920ENPain Research and Management, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Mirian López María Luz Padilla Blas García Javier Orozco Ana María Rodilla Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
description	Background. Acute postoperative pain (APP) has a high incidence in breast surgery, and opioids are the most commonly used drugs for its management; however, they are not free from systemic side effects, which may increase comorbidity. In the past few years, opioid-free anaesthesia has been favoured with promising results. Methods. We conducted a descriptive study including 71 patients who underwent breast cancer surgery. The opioid group (n = 41) received fentanyl for induction, remifentanil for maintenance, and rescue morphine before waking up, whereas the ketamine group (n = 30) received a ketamine bolus for induction followed by continuous ketamine infusion during surgery. Later, the presence and intensity of pain were registered, using the Numeric Rating Scale (NRS 1–10) for pain, at different times in the recovery room, at 24 hours and at 3 months. Results. Administration of ketamine is more effective than opioid use for APP prevention in breast cancer surgery because the ketamine group presented with less pain than the opioid group (p < 0.05) at all measured times. When there was pain, patients in the ketamine group gave a lower score to its intensity (p < 0.05). Conclusions. Ketamine could reduce the incidence of APP in breast cancer surgery, compared to opioids.
format	article
author	Mirian López María Luz Padilla Blas García Javier Orozco Ana María Rodilla
author_facet	Mirian López María Luz Padilla Blas García Javier Orozco Ana María Rodilla
author_sort	Mirian López
title	Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
title_short	Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
title_full	Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
title_fullStr	Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
title_full_unstemmed	Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia
title_sort	prevention of acute postoperative pain in breast cancer: a comparison between opioids versus ketamine in the intraoperatory analgesia
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/3a464b35691e401d9c14eeec13b45e27
work_keys_str_mv	AT mirianlopez preventionofacutepostoperativepaininbreastcanceracomparisonbetweenopioidsversusketamineintheintraoperatoryanalgesia AT marialuzpadilla preventionofacutepostoperativepaininbreastcanceracomparisonbetweenopioidsversusketamineintheintraoperatoryanalgesia AT blasgarcia preventionofacutepostoperativepaininbreastcanceracomparisonbetweenopioidsversusketamineintheintraoperatoryanalgesia AT javierorozco preventionofacutepostoperativepaininbreastcanceracomparisonbetweenopioidsversusketamineintheintraoperatoryanalgesia AT anamariarodilla preventionofacutepostoperativepaininbreastcanceracomparisonbetweenopioidsversusketamineintheintraoperatoryanalgesia
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Prevention of Acute Postoperative Pain in Breast Cancer: A Comparison between Opioids versus Ketamine in the Intraoperatory Analgesia

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