Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.

The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few p...

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Autores principales:	Daniel Havelka, Ondřej Kučera, Marco A Deriu, Michal Cifra
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a4832bfd858466e8e243aee0d4e84b2
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spelling	oai:doaj.org-article:3a4832bfd858466e8e243aee0d4e84b22021-11-18T08:34:53ZElectro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.1932-620310.1371/journal.pone.0086501https://doaj.org/article/3a4832bfd858466e8e243aee0d4e84b22014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24497952/?tool=EBIhttps://doaj.org/toc/1932-6203The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells--a strategy used in novel methods for cancer treatment.Daniel HavelkaOndřej KučeraMarco A DeriuMichal CifraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e86501 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daniel Havelka Ondřej Kučera Marco A Deriu Michal Cifra Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
description	The regulation of chromosome separation during mitosis is not fully understood yet. Microtubules forming mitotic spindles are targets of treatment strategies which are aimed at (i) the triggering of the apoptosis or (ii) the interruption of uncontrolled cell division. Despite these facts, only few physical models relating to the dynamics of mitotic spindles exist up to now. In this paper, we present the first electromechanical model which enables calculation of the electromagnetic field coupled to acoustic vibrations of the mitotic spindle. This electromagnetic field originates from the electrical polarity of microtubules which form the mitotic spindle. The model is based on the approximation of resonantly vibrating microtubules by a network of oscillating electric dipoles. Our computational results predict the existence of a rapidly changing electric field which is generated by either driven or endogenous vibrations of the mitotic spindle. For certain values of parameters, the intensity of the electric field and its gradient reach values which may exert a not-inconsiderable force on chromosomes which are aligned in the spindle midzone. Our model may describe possible mechanisms of the effects of ultra-short electrical and mechanical pulses on dividing cells--a strategy used in novel methods for cancer treatment.
format	article
author	Daniel Havelka Ondřej Kučera Marco A Deriu Michal Cifra
author_facet	Daniel Havelka Ondřej Kučera Marco A Deriu Michal Cifra
author_sort	Daniel Havelka
title	Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
title_short	Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
title_full	Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
title_fullStr	Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
title_full_unstemmed	Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
title_sort	electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3a4832bfd858466e8e243aee0d4e84b2
work_keys_str_mv	AT danielhavelka electroacousticbehaviorofthemitoticspindleasemiclassicalcoarsegrainedmodel AT ondrejkucera electroacousticbehaviorofthemitoticspindleasemiclassicalcoarsegrainedmodel AT marcoaderiu electroacousticbehaviorofthemitoticspindleasemiclassicalcoarsegrainedmodel AT michalcifra electroacousticbehaviorofthemitoticspindleasemiclassicalcoarsegrainedmodel
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Electro-acoustic behavior of the mitotic spindle: a semi-classical coarse-grained model.

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