Age and life expectancy clocks based on machine learning analysis of mouse frailty

The discovery of interventions that slow aging could be accelerated by employing non-invasive biometrics that predict biological age or life expectancy. Here the authors use longitudinal frailty data from naturally aging mice to develop two such tools, that are responsive to interventions.

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Autores principales:	Michael B. Schultz, Alice E. Kane, Sarah J. Mitchell, Michael R. MacArthur, Elisa Warner, David S. Vogel, James R. Mitchell, Susan E. Howlett, Michael S. Bonkowski, David A. Sinclair
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a49ccbd63f44865818e20ab50fb5065
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spelling	oai:doaj.org-article:3a49ccbd63f44865818e20ab50fb50652021-12-02T18:34:02ZAge and life expectancy clocks based on machine learning analysis of mouse frailty10.1038/s41467-020-18446-02041-1723https://doaj.org/article/3a49ccbd63f44865818e20ab50fb50652020-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18446-0https://doaj.org/toc/2041-1723The discovery of interventions that slow aging could be accelerated by employing non-invasive biometrics that predict biological age or life expectancy. Here the authors use longitudinal frailty data from naturally aging mice to develop two such tools, that are responsive to interventions.Michael B. SchultzAlice E. KaneSarah J. MitchellMichael R. MacArthurElisa WarnerDavid S. VogelJames R. MitchellSusan E. HowlettMichael S. BonkowskiDavid A. SinclairNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael B. Schultz Alice E. Kane Sarah J. Mitchell Michael R. MacArthur Elisa Warner David S. Vogel James R. Mitchell Susan E. Howlett Michael S. Bonkowski David A. Sinclair Age and life expectancy clocks based on machine learning analysis of mouse frailty
description	The discovery of interventions that slow aging could be accelerated by employing non-invasive biometrics that predict biological age or life expectancy. Here the authors use longitudinal frailty data from naturally aging mice to develop two such tools, that are responsive to interventions.
format	article
author	Michael B. Schultz Alice E. Kane Sarah J. Mitchell Michael R. MacArthur Elisa Warner David S. Vogel James R. Mitchell Susan E. Howlett Michael S. Bonkowski David A. Sinclair
author_facet	Michael B. Schultz Alice E. Kane Sarah J. Mitchell Michael R. MacArthur Elisa Warner David S. Vogel James R. Mitchell Susan E. Howlett Michael S. Bonkowski David A. Sinclair
author_sort	Michael B. Schultz
title	Age and life expectancy clocks based on machine learning analysis of mouse frailty
title_short	Age and life expectancy clocks based on machine learning analysis of mouse frailty
title_full	Age and life expectancy clocks based on machine learning analysis of mouse frailty
title_fullStr	Age and life expectancy clocks based on machine learning analysis of mouse frailty
title_full_unstemmed	Age and life expectancy clocks based on machine learning analysis of mouse frailty
title_sort	age and life expectancy clocks based on machine learning analysis of mouse frailty
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a49ccbd63f44865818e20ab50fb5065
work_keys_str_mv	AT michaelbschultz ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT aliceekane ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT sarahjmitchell ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT michaelrmacarthur ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT elisawarner ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT davidsvogel ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT jamesrmitchell ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT susanehowlett ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT michaelsbonkowski ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty AT davidasinclair ageandlifeexpectancyclocksbasedonmachinelearninganalysisofmousefrailty
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Age and life expectancy clocks based on machine learning analysis of mouse frailty

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