Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.

<h4>Introduction</h4>Skeletal muscle mass loss has been associated with decreased physical performance; however, the body composition characteristics in progressive supranuclear palsy (PSP) are not well understood. We investigated body composition parameters, focusing on skeletal muscle...

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Autores principales:	Yasuyuki Takamatsu, Ikuko Aiba
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a4b3b50eb594a5fb33b01f77e392342
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spelling	oai:doaj.org-article:3a4b3b50eb594a5fb33b01f77e3923422021-12-02T20:10:46ZSkeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.1932-620310.1371/journal.pone.0253079https://doaj.org/article/3a4b3b50eb594a5fb33b01f77e3923422021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253079https://doaj.org/toc/1932-6203<h4>Introduction</h4>Skeletal muscle mass loss has been associated with decreased physical performance; however, the body composition characteristics in progressive supranuclear palsy (PSP) are not well understood. We investigated body composition parameters, focusing on skeletal muscle mass, in patients with PSP and compared them with those of healthy older adults.<h4>Methods</h4>This retrospective cross-sectional study included 39 patients with PSP and 30 healthy older adults (control group). Using a multi-frequency bioelectrical impedance analysis, we measured the skeletal mass index (SMI), basal metabolism, extracellular water/total body water ratio (ECW/TBW), and body fat percentage and examined the relationship between SMI and age, body mass index (BMI) and other body composition parameters.<h4>Results</h4>The PSP group had a higher rate of low muscle mass (56.4%) than the control group (10.0%), although the ages and BMIs were similar. The leg SMI was lower for the PSP group, while the ECW/TBW was higher for the PSP group. The basal metabolism was lower for the PSP group than for the controls but only in the women. The basal metabolism and BMI showed a significant correlation with SMI in the PSP group. There was a significant correlation between SMI and age, ECW/TBW, and body fat percentage in the PSP group but only in the women.<h4>Conclusion</h4>This study is the first to show that a high proportion of patients with PSP have low muscle mass. We showed differences in terms of sex in muscle mass loss in women with PSP, which was associated with inactivity and aging.Yasuyuki TakamatsuIkuko AibaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253079 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuyuki Takamatsu Ikuko Aiba Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
description	<h4>Introduction</h4>Skeletal muscle mass loss has been associated with decreased physical performance; however, the body composition characteristics in progressive supranuclear palsy (PSP) are not well understood. We investigated body composition parameters, focusing on skeletal muscle mass, in patients with PSP and compared them with those of healthy older adults.<h4>Methods</h4>This retrospective cross-sectional study included 39 patients with PSP and 30 healthy older adults (control group). Using a multi-frequency bioelectrical impedance analysis, we measured the skeletal mass index (SMI), basal metabolism, extracellular water/total body water ratio (ECW/TBW), and body fat percentage and examined the relationship between SMI and age, body mass index (BMI) and other body composition parameters.<h4>Results</h4>The PSP group had a higher rate of low muscle mass (56.4%) than the control group (10.0%), although the ages and BMIs were similar. The leg SMI was lower for the PSP group, while the ECW/TBW was higher for the PSP group. The basal metabolism was lower for the PSP group than for the controls but only in the women. The basal metabolism and BMI showed a significant correlation with SMI in the PSP group. There was a significant correlation between SMI and age, ECW/TBW, and body fat percentage in the PSP group but only in the women.<h4>Conclusion</h4>This study is the first to show that a high proportion of patients with PSP have low muscle mass. We showed differences in terms of sex in muscle mass loss in women with PSP, which was associated with inactivity and aging.
format	article
author	Yasuyuki Takamatsu Ikuko Aiba
author_facet	Yasuyuki Takamatsu Ikuko Aiba
author_sort	Yasuyuki Takamatsu
title	Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
title_short	Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
title_full	Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
title_fullStr	Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
title_full_unstemmed	Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.
title_sort	skeletal muscle loss and body composition in progressive supranuclear palsy: a retrospective cross-sectional study.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/3a4b3b50eb594a5fb33b01f77e392342
work_keys_str_mv	AT yasuyukitakamatsu skeletalmusclelossandbodycompositioninprogressivesupranuclearpalsyaretrospectivecrosssectionalstudy AT ikukoaiba skeletalmusclelossandbodycompositioninprogressivesupranuclearpalsyaretrospectivecrosssectionalstudy
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Skeletal muscle loss and body composition in progressive supranuclear palsy: A retrospective cross-sectional study.

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