Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases

Objective To analyze the risk factors of late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods We retrospectively analyzed 227 patients who underwent allo-HSCT in our hospital from 2016 to 2020. Univariate and multivariate analyses were...

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Autores principales:	XIONG Yiying, CAI Duo, CHEN Jianbin, LUO Xiaohua, TANG Xiaoqiong
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Office of Journal of Third Military Medical University 2021
Materias:	allogeneic hematopoietic stem cell transplantation late-onset hemorrhagic cystitis risk factors Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a4c1f8052534cf2bef0d560f773ee27
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spelling	oai:doaj.org-article:3a4c1f8052534cf2bef0d560f773ee272021-11-12T04:47:01ZRisk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases10.16016/j.1000-5404.2021080441000-5404https://doaj.org/article/3a4c1f8052534cf2bef0d560f773ee272021-11-01T00:00:00Zhttp://aammt.tmmu.edu.cn/Upload/rhtml/202108044.htmhttps://doaj.org/toc/1000-5404Objective To analyze the risk factors of late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods We retrospectively analyzed 227 patients who underwent allo-HSCT in our hospital from 2016 to 2020. Univariate and multivariate analyses were performed in 215 patients with hematopoietic reconstitution for the clinical factors related to LOHC, and survival analysis and subgroup analysis were also carried out. Results LOHC occurred in 72 (31.7%) patients at a median 31 (8~80) d after allo-HSCT, for a median duration of 24 (3~100) d. The results of univariate and multivariate analyses indicated that gender incompatibility in donors and recipients, intensified conditioning regimen with fludarabine/cladribine and cytarabine, cytomegalovirus (CMV)-DNA positive and acute graft-versus-host disease (aGVHD) significantly increased the incidence of LOHC (P=0.025, < 0.001, 0.021 and 0.028, respectively). The LOHC patients had a lower overall survival (OS) rate than those without (P=0.035), moreover, those with aGVHD simultaneously had worse OS rate than those without (P=0.005). Subgroup analysis of acute leukemia (AL) showed that patients in first complete remission (CR1) before allo-HSCT had a lower incidence of LOHC than others (OR=2.964, 95%CI: 1.255~7.003, P=0.013). Conclusion Gender incompatibility in donors and recipients, intensified conditioning regimen (including FA/CA), CMV-DNA positive and aGVHD are independent risk factors for LOHC.XIONG YiyingCAI DuoCHEN JianbinLUO XiaohuaTANG XiaoqiongEditorial Office of Journal of Third Military Medical Universityarticleallogeneic hematopoietic stem cell transplantationlate-onset hemorrhagic cystitisrisk factorsMedicine (General)R5-920ZHDi-san junyi daxue xuebao, Vol 43, Iss 21, Pp 2321-2330 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	allogeneic hematopoietic stem cell transplantation late-onset hemorrhagic cystitis risk factors Medicine (General) R5-920
spellingShingle	allogeneic hematopoietic stem cell transplantation late-onset hemorrhagic cystitis risk factors Medicine (General) R5-920 XIONG Yiying CAI Duo CHEN Jianbin LUO Xiaohua TANG Xiaoqiong Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
description	Objective To analyze the risk factors of late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Methods We retrospectively analyzed 227 patients who underwent allo-HSCT in our hospital from 2016 to 2020. Univariate and multivariate analyses were performed in 215 patients with hematopoietic reconstitution for the clinical factors related to LOHC, and survival analysis and subgroup analysis were also carried out. Results LOHC occurred in 72 (31.7%) patients at a median 31 (8~80) d after allo-HSCT, for a median duration of 24 (3~100) d. The results of univariate and multivariate analyses indicated that gender incompatibility in donors and recipients, intensified conditioning regimen with fludarabine/cladribine and cytarabine, cytomegalovirus (CMV)-DNA positive and acute graft-versus-host disease (aGVHD) significantly increased the incidence of LOHC (P=0.025, < 0.001, 0.021 and 0.028, respectively). The LOHC patients had a lower overall survival (OS) rate than those without (P=0.035), moreover, those with aGVHD simultaneously had worse OS rate than those without (P=0.005). Subgroup analysis of acute leukemia (AL) showed that patients in first complete remission (CR1) before allo-HSCT had a lower incidence of LOHC than others (OR=2.964, 95%CI: 1.255~7.003, P=0.013). Conclusion Gender incompatibility in donors and recipients, intensified conditioning regimen (including FA/CA), CMV-DNA positive and aGVHD are independent risk factors for LOHC.
format	article
author	XIONG Yiying CAI Duo CHEN Jianbin LUO Xiaohua TANG Xiaoqiong
author_facet	XIONG Yiying CAI Duo CHEN Jianbin LUO Xiaohua TANG Xiaoqiong
author_sort	XIONG Yiying
title	Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
title_short	Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
title_full	Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
title_fullStr	Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
title_full_unstemmed	Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
title_sort	risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases
publisher	Editorial Office of Journal of Third Military Medical University
publishDate	2021
url	https://doaj.org/article/3a4c1f8052534cf2bef0d560f773ee27
work_keys_str_mv	AT xiongyiying riskfactorsforlateonsethemorrhagiccystitisafterallogeneichematopoieticstemcelltransplantationanalysisof227cases AT caiduo riskfactorsforlateonsethemorrhagiccystitisafterallogeneichematopoieticstemcelltransplantationanalysisof227cases AT chenjianbin riskfactorsforlateonsethemorrhagiccystitisafterallogeneichematopoieticstemcelltransplantationanalysisof227cases AT luoxiaohua riskfactorsforlateonsethemorrhagiccystitisafterallogeneichematopoieticstemcelltransplantationanalysisof227cases AT tangxiaoqiong riskfactorsforlateonsethemorrhagiccystitisafterallogeneichematopoieticstemcelltransplantationanalysisof227cases
_version_	1718431225268404224

Risk factors for late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: analysis of 227 cases

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