Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI

Abstract The present study systemically investigated the influence of gated/non-gated sequences, velocity encoding (VENC), and spatial resolution on blood flow, wall shear stress (WSS), and artery area evaluations when scanning the common carotid artery (CCA) in rats using phase-contrast magnetic re...

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Autores principales:	Shin-Lei Peng, Cheng-Ting Shih, Chiun-Wei Huang, Shao-Chieh Chiu, Wu-Chung Shen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a4d6b35bd0b433ba61936475af64262
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spelling	oai:doaj.org-article:3a4d6b35bd0b433ba61936475af642622021-12-02T11:40:44ZOptimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI10.1038/s41598-017-05606-42045-2322https://doaj.org/article/3a4d6b35bd0b433ba61936475af642622017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05606-4https://doaj.org/toc/2045-2322Abstract The present study systemically investigated the influence of gated/non-gated sequences, velocity encoding (VENC), and spatial resolution on blood flow, wall shear stress (WSS), and artery area evaluations when scanning the common carotid artery (CCA) in rats using phase-contrast magnetic resonance imaging (PC-MRI). We first tested whether or not non-gated PC-MRI was appropriate for evaluating blood flow and WSS in rats. For both gated and non-gated techniques, VENC values in the range of 60–120 cm/s with an interval of 10 cm/s were also tested. Second, we optimized the in-plane resolution of PC-MRI for blood flow and WSS measurements. Results showed the usage of a gated instrument can provide more reproducible assessments, whereas VENC had an insignificant influence on all hemodynamic measurements (all P > 0.05). Lower resolutions, such as 0.63 mm, led to significant overestimations in blood flow and artery area quantifications and to an underestimation in WSS measurements (all P < 0.05). However, a higher resolution of 0.16 mm slightly increased measurement variation. As a tradeoff between accuracy and scan time, we propose a gated PC-MRI sequence with a VENC of 120 cm/s and a resolution of 0.21 mm to be used to extract hemodynamic information about rat CCA.Shin-Lei PengCheng-Ting ShihChiun-Wei HuangShao-Chieh ChiuWu-Chung ShenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shin-Lei Peng Cheng-Ting Shih Chiun-Wei Huang Shao-Chieh Chiu Wu-Chung Shen Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
description	Abstract The present study systemically investigated the influence of gated/non-gated sequences, velocity encoding (VENC), and spatial resolution on blood flow, wall shear stress (WSS), and artery area evaluations when scanning the common carotid artery (CCA) in rats using phase-contrast magnetic resonance imaging (PC-MRI). We first tested whether or not non-gated PC-MRI was appropriate for evaluating blood flow and WSS in rats. For both gated and non-gated techniques, VENC values in the range of 60–120 cm/s with an interval of 10 cm/s were also tested. Second, we optimized the in-plane resolution of PC-MRI for blood flow and WSS measurements. Results showed the usage of a gated instrument can provide more reproducible assessments, whereas VENC had an insignificant influence on all hemodynamic measurements (all P > 0.05). Lower resolutions, such as 0.63 mm, led to significant overestimations in blood flow and artery area quantifications and to an underestimation in WSS measurements (all P < 0.05). However, a higher resolution of 0.16 mm slightly increased measurement variation. As a tradeoff between accuracy and scan time, we propose a gated PC-MRI sequence with a VENC of 120 cm/s and a resolution of 0.21 mm to be used to extract hemodynamic information about rat CCA.
format	article
author	Shin-Lei Peng Cheng-Ting Shih Chiun-Wei Huang Shao-Chieh Chiu Wu-Chung Shen
author_facet	Shin-Lei Peng Cheng-Ting Shih Chiun-Wei Huang Shao-Chieh Chiu Wu-Chung Shen
author_sort	Shin-Lei Peng
title	Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
title_short	Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
title_full	Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
title_fullStr	Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
title_full_unstemmed	Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI
title_sort	optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast mri
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3a4d6b35bd0b433ba61936475af64262
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Optimized analysis of blood flow and wall shear stress in the common carotid artery of rat model by phase-contrast MRI

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