Retinal Organoids: Cultivation, Differentiation, and Transplantation

Retinal organoids (ROs), which are derived from stem cells, can automatically form three-dimensional laminar structures that include all cell types and the ultrastructure of the retina. Therefore, they are highly similar to the retinal structure in the human body. The development of organoids has be...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xuying Li, Li Zhang, Fei Tang, Xin Wei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	retinal organoid stem cell retinal ganglion cell photoreceptor cell replacement therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/3a4e45e5a8f744aa9862b3a490d566ba
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3a4e45e5a8f744aa9862b3a490d566ba
record_format	dspace
spelling	oai:doaj.org-article:3a4e45e5a8f744aa9862b3a490d566ba2021-12-02T12:11:21ZRetinal Organoids: Cultivation, Differentiation, and Transplantation1662-510210.3389/fncel.2021.638439https://doaj.org/article/3a4e45e5a8f744aa9862b3a490d566ba2021-06-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncel.2021.638439/fullhttps://doaj.org/toc/1662-5102Retinal organoids (ROs), which are derived from stem cells, can automatically form three-dimensional laminar structures that include all cell types and the ultrastructure of the retina. Therefore, they are highly similar to the retinal structure in the human body. The development of organoids has been a great technological breakthrough in the fields of transplantation therapy and disease modeling. However, the translation of RO applications into medical practice still has various deficiencies at the current stage, including the long culture process, insufficient yield, and great heterogeneity among ROs produced under different conditions. Nevertheless, many technological breakthroughs have been made in transplanting ROs for treatment of diseases such as retinal degeneration. This review discusses recent advances in the development of ROs, improvements of the culture protocol, and the latest developments in RO replacement therapy techniques.Xuying LiLi ZhangFei TangXin WeiXin WeiFrontiers Media S.A.articleretinal organoidstem cellretinal ganglion cellphotoreceptor cellreplacement therapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Cellular Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	retinal organoid stem cell retinal ganglion cell photoreceptor cell replacement therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	retinal organoid stem cell retinal ganglion cell photoreceptor cell replacement therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Xuying Li Li Zhang Fei Tang Xin Wei Xin Wei Retinal Organoids: Cultivation, Differentiation, and Transplantation
description	Retinal organoids (ROs), which are derived from stem cells, can automatically form three-dimensional laminar structures that include all cell types and the ultrastructure of the retina. Therefore, they are highly similar to the retinal structure in the human body. The development of organoids has been a great technological breakthrough in the fields of transplantation therapy and disease modeling. However, the translation of RO applications into medical practice still has various deficiencies at the current stage, including the long culture process, insufficient yield, and great heterogeneity among ROs produced under different conditions. Nevertheless, many technological breakthroughs have been made in transplanting ROs for treatment of diseases such as retinal degeneration. This review discusses recent advances in the development of ROs, improvements of the culture protocol, and the latest developments in RO replacement therapy techniques.
format	article
author	Xuying Li Li Zhang Fei Tang Xin Wei Xin Wei
author_facet	Xuying Li Li Zhang Fei Tang Xin Wei Xin Wei
author_sort	Xuying Li
title	Retinal Organoids: Cultivation, Differentiation, and Transplantation
title_short	Retinal Organoids: Cultivation, Differentiation, and Transplantation
title_full	Retinal Organoids: Cultivation, Differentiation, and Transplantation
title_fullStr	Retinal Organoids: Cultivation, Differentiation, and Transplantation
title_full_unstemmed	Retinal Organoids: Cultivation, Differentiation, and Transplantation
title_sort	retinal organoids: cultivation, differentiation, and transplantation
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3a4e45e5a8f744aa9862b3a490d566ba
work_keys_str_mv	AT xuyingli retinalorganoidscultivationdifferentiationandtransplantation AT lizhang retinalorganoidscultivationdifferentiationandtransplantation AT feitang retinalorganoidscultivationdifferentiationandtransplantation AT xinwei retinalorganoidscultivationdifferentiationandtransplantation AT xinwei retinalorganoidscultivationdifferentiationandtransplantation
_version_	1718394621635067904

Retinal Organoids: Cultivation, Differentiation, and Transplantation

Ejemplares similares