Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late mRNAs.

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Autores principales:	Alexander M. Price, Katharina E. Hayer, Alexa B. R. McIntyre, Nandan S. Gokhale, Jonathan S. Abebe, Ashley N. Della Fera, Christopher E. Mason, Stacy M. Horner, Angus C. Wilson, Daniel P. Depledge, Matthew D. Weitzman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a519d8fdd744f07aceaf2a7bd692439
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spelling	oai:doaj.org-article:3a519d8fdd744f07aceaf2a7bd6924392021-12-02T15:37:16ZDirect RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing10.1038/s41467-020-19787-62041-1723https://doaj.org/article/3a519d8fdd744f07aceaf2a7bd6924392020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19787-6https://doaj.org/toc/2041-1723Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late mRNAs.Alexander M. PriceKatharina E. HayerAlexa B. R. McIntyreNandan S. GokhaleJonathan S. AbebeAshley N. Della FeraChristopher E. MasonStacy M. HornerAngus C. WilsonDaniel P. DepledgeMatthew D. WeitzmanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander M. Price Katharina E. Hayer Alexa B. R. McIntyre Nandan S. Gokhale Jonathan S. Abebe Ashley N. Della Fera Christopher E. Mason Stacy M. Horner Angus C. Wilson Daniel P. Depledge Matthew D. Weitzman Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
description	Adenovirus transcripts contain N6-methyladenosine (m6A) modification. Here the authors profile m6A modification sites on adenovirus mRNAs using Illumina meRIP-Seq and nanopore direct RNA sequencing, and showcase a role for m6A in splicing of viral late mRNAs.
format	article
author	Alexander M. Price Katharina E. Hayer Alexa B. R. McIntyre Nandan S. Gokhale Jonathan S. Abebe Ashley N. Della Fera Christopher E. Mason Stacy M. Horner Angus C. Wilson Daniel P. Depledge Matthew D. Weitzman
author_facet	Alexander M. Price Katharina E. Hayer Alexa B. R. McIntyre Nandan S. Gokhale Jonathan S. Abebe Ashley N. Della Fera Christopher E. Mason Stacy M. Horner Angus C. Wilson Daniel P. Depledge Matthew D. Weitzman
author_sort	Alexander M. Price
title	Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
title_short	Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
title_full	Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
title_fullStr	Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
title_full_unstemmed	Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing
title_sort	direct rna sequencing reveals m6a modifications on adenovirus rna are necessary for efficient splicing
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a519d8fdd744f07aceaf2a7bd692439
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Direct RNA sequencing reveals m6A modifications on adenovirus RNA are necessary for efficient splicing

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