Engineering a PAM-flexible SpdCas9 variant as a universal gene repressor

Engineering a PAM-flexible SpdCas9 variant as a universal gene repressor

SpCas9 has a NGG PAM requirement that limits its DNA target range. Here the authors present a PAM-expanded SpdCas9 variant SpdNG-LWQT to target NRN PAMs.

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Detalles Bibliográficos
Autores principales: Jian Wang, Yuxi Teng, Ruihua Zhang, Yifei Wu, Lei Lou, Yusong Zou, Michelle Li, Zhong-Ru Xie, Yajun Yan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
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Acceso en línea:https://doaj.org/article/3a51c52620b74b36aec06b2ae3c5ca95
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