Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

Devin Wahl,1,2 Sean CP Coogan,1,3 Samantha M Solon-Biet,1,2 Rafael de Cabo,4 James B Haran,5 David Raubenheimer,1,6,7 Victoria C Cogger,1,2 Mark P Mattson,8 Stephen J Simpson,1,2,7 David G Le Couteur1,2 1Charles Perkins Centre, University of Sydney, Sydney, 2Aging and Alzheimers Institute, ANZAC Re...

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Autores principales:	Wahl D, Coogan SCP, Solon-Biet SM, de Cabo R, Haran JB, Raubenheimer D, Cogger VC, Mattson MP, Simpson SJ, Le Couteur DG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Calorie restriction intermittent fasting aging memory macronutrients Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/3a53818c76994f8582658726b0754e57
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spelling	oai:doaj.org-article:3a53818c76994f8582658726b0754e572021-12-02T07:15:31ZCognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia1178-1998https://doaj.org/article/3a53818c76994f8582658726b0754e572017-09-01T00:00:00Zhttps://www.dovepress.com/cognitive-and-behavioral-evaluation-of-nutritional-interventions-in-ro-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Devin Wahl,1,2 Sean CP Coogan,1,3 Samantha M Solon-Biet,1,2 Rafael de Cabo,4 James B Haran,5 David Raubenheimer,1,6,7 Victoria C Cogger,1,2 Mark P Mattson,8 Stephen J Simpson,1,2,7 David G Le Couteur1,2 1Charles Perkins Centre, University of Sydney, Sydney, 2Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW, Australia; 3Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada; 4Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; 5Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA; 6Faculty of Veterinary Science, 7School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia; 8Laboratory of Neurosciences, National Institute on Aging’s Intramural Research Program, National Institutes of Health, Baltimore, MD, USA Abstract: Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration. Keywords: calorie restriction, intermittent fasting, aging, memory, macronutrientsWahl DCoogan SCPSolon-Biet SMde Cabo RHaran JBRaubenheimer DCogger VCMattson MPSimpson SJLe Couteur DGDove Medical PressarticleCalorie restrictionintermittent fastingagingmemorymacronutrientsGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 12, Pp 1419-1428 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Calorie restriction intermittent fasting aging memory macronutrients Geriatrics RC952-954.6
spellingShingle	Calorie restriction intermittent fasting aging memory macronutrients Geriatrics RC952-954.6 Wahl D Coogan SCP Solon-Biet SM de Cabo R Haran JB Raubenheimer D Cogger VC Mattson MP Simpson SJ Le Couteur DG Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
description	Devin Wahl,1,2 Sean CP Coogan,1,3 Samantha M Solon-Biet,1,2 Rafael de Cabo,4 James B Haran,5 David Raubenheimer,1,6,7 Victoria C Cogger,1,2 Mark P Mattson,8 Stephen J Simpson,1,2,7 David G Le Couteur1,2 1Charles Perkins Centre, University of Sydney, Sydney, 2Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord, NSW, Australia; 3Department of Renewable Resources, University of Alberta, Edmonton, AB, Canada; 4Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA; 5Philadelphia College of Osteopathic Medicine, Philadelphia, PA, USA; 6Faculty of Veterinary Science, 7School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia; 8Laboratory of Neurosciences, National Institute on Aging’s Intramural Research Program, National Institutes of Health, Baltimore, MD, USA Abstract: Evaluation of behavior and cognition in rodent models underpins mechanistic and interventional studies of brain aging and neurodegenerative diseases, especially dementia. Commonly used tests include Morris water maze, Barnes maze, object recognition, fear conditioning, radial arm water maze, and Y maze. Each of these tests reflects some aspects of human memory including episodic memory, recognition memory, semantic memory, spatial memory, and emotional memory. Although most interventional studies in rodent models of dementia have focused on pharmacological agents, there are an increasing number of studies that have evaluated nutritional interventions including caloric restriction, intermittent fasting, and manipulation of macronutrients. Dietary interventions have been shown to influence various cognitive and behavioral tests in rodents indicating that nutrition can influence brain aging and possibly neurodegeneration. Keywords: calorie restriction, intermittent fasting, aging, memory, macronutrients
format	article
author	Wahl D Coogan SCP Solon-Biet SM de Cabo R Haran JB Raubenheimer D Cogger VC Mattson MP Simpson SJ Le Couteur DG
author_facet	Wahl D Coogan SCP Solon-Biet SM de Cabo R Haran JB Raubenheimer D Cogger VC Mattson MP Simpson SJ Le Couteur DG
author_sort	Wahl D
title	Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
title_short	Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
title_full	Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
title_fullStr	Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
title_full_unstemmed	Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
title_sort	cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/3a53818c76994f8582658726b0754e57
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_version_	1718399512096014336

Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia

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