Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide formation, and can be removed with N-chlorosuccinimi...

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Autores principales:	Kevin Neumann, Jakob Farnung, Simon Baldauf, Jeffrey W. Bode
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a53cea2ef4a4ca2918b069de286b275
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spelling	oai:doaj.org-article:3a53cea2ef4a4ca2918b069de286b2752021-12-02T14:40:28ZPrevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups10.1038/s41467-020-14755-62041-1723https://doaj.org/article/3a53cea2ef4a4ca2918b069de286b2752020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14755-6https://doaj.org/toc/2041-1723Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide formation, and can be removed with N-chlorosuccinimide.Kevin NeumannJakob FarnungSimon BaldaufJeffrey W. BodeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kevin Neumann Jakob Farnung Simon Baldauf Jeffrey W. Bode Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
description	Aspartimide formation is a frequently occurring problem during peptide synthesis. Here, the authors present cyanosulfurylides as a protection group that masks aspartic acid residues during solid phase peptide synthesis, thus preventing aspartimide formation, and can be removed with N-chlorosuccinimide.
format	article
author	Kevin Neumann Jakob Farnung Simon Baldauf Jeffrey W. Bode
author_facet	Kevin Neumann Jakob Farnung Simon Baldauf Jeffrey W. Bode
author_sort	Kevin Neumann
title	Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
title_short	Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
title_full	Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
title_fullStr	Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
title_full_unstemmed	Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
title_sort	prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a53cea2ef4a4ca2918b069de286b275
work_keys_str_mv	AT kevinneumann preventionofaspartimideformationduringpeptidesynthesisusingcyanosulfurylidesascarboxylicacidprotectinggroups AT jakobfarnung preventionofaspartimideformationduringpeptidesynthesisusingcyanosulfurylidesascarboxylicacidprotectinggroups AT simonbaldauf preventionofaspartimideformationduringpeptidesynthesisusingcyanosulfurylidesascarboxylicacidprotectinggroups AT jeffreywbode preventionofaspartimideformationduringpeptidesynthesisusingcyanosulfurylidesascarboxylicacidprotectinggroups
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Prevention of aspartimide formation during peptide synthesis using cyanosulfurylides as carboxylic acid-protecting groups

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