Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy

Abstract Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritabi...

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Autores principales:	Tsegaselassie Workalemahu, Katherine L. Grantz, Jagteshwar Grewal, Cuilin Zhang, Germaine M. Buck Louis, Fasil Tekola-Ayele
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a5563e7dde647ecb204a62d73979d69
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spelling	oai:doaj.org-article:3a5563e7dde647ecb204a62d73979d692021-12-02T16:08:01ZGenetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy10.1038/s41598-018-25706-z2045-2322https://doaj.org/article/3a5563e7dde647ecb204a62d73979d692018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25706-zhttps://doaj.org/toc/2045-2322Abstract Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC = 53%, HL = 57%, FL = 72%, EFW = 71%; p < 0.05). In contrast, shared environment explained most of phenotypic variations in fetal growth in the first trimester (AC = 50%, HL = 54%, FL = 47%, EFW = 54%; p < 0.05), suggesting that the first trimester presents an intervention opportunity for a more optimal early fetal growth. Genetic correlations between growth traits (range 0.34–1.00; p < 0.05) were strongest at the end of first trimester and declined with gestation, suggesting that different fetal growth measures are more likely to be influenced by the same genes in early pregnancy.Tsegaselassie WorkalemahuKatherine L. GrantzJagteshwar GrewalCuilin ZhangGermaine M. Buck LouisFasil Tekola-AyeleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tsegaselassie Workalemahu Katherine L. Grantz Jagteshwar Grewal Cuilin Zhang Germaine M. Buck Louis Fasil Tekola-Ayele Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
description	Abstract Aberrant fetal growth is associated with morbidities and mortality during childhood and adult life. Although genetic and environmental factors are known to influence in utero growth, their relative contributions over pregnancy is unknown. We estimated, across gestation, the genetic heritability, contribution of shared environment, and genetic correlations of fetal growth measures (abdominal circumference (AC), humerus length (HL), femur length (FL), and estimated fetal weight (EFW)) in a prospective cohort of dichorionic twin gestations recruited through the NICHD Fetal Growth Studies. Structural equation models were fit at the end of first trimester, during mid-gestation, late second trimester, and third trimester of pregnancy. The contribution of fetal genetics on fetal size increased with gestational age, peaking in late second trimester (AC = 53%, HL = 57%, FL = 72%, EFW = 71%; p < 0.05). In contrast, shared environment explained most of phenotypic variations in fetal growth in the first trimester (AC = 50%, HL = 54%, FL = 47%, EFW = 54%; p < 0.05), suggesting that the first trimester presents an intervention opportunity for a more optimal early fetal growth. Genetic correlations between growth traits (range 0.34–1.00; p < 0.05) were strongest at the end of first trimester and declined with gestation, suggesting that different fetal growth measures are more likely to be influenced by the same genes in early pregnancy.
format	article
author	Tsegaselassie Workalemahu Katherine L. Grantz Jagteshwar Grewal Cuilin Zhang Germaine M. Buck Louis Fasil Tekola-Ayele
author_facet	Tsegaselassie Workalemahu Katherine L. Grantz Jagteshwar Grewal Cuilin Zhang Germaine M. Buck Louis Fasil Tekola-Ayele
author_sort	Tsegaselassie Workalemahu
title	Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
title_short	Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
title_full	Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
title_fullStr	Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
title_full_unstemmed	Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy
title_sort	genetic and environmental influences on fetal growth vary during sensitive periods in pregnancy
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3a5563e7dde647ecb204a62d73979d69
work_keys_str_mv	AT tsegaselassieworkalemahu geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy AT katherinelgrantz geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy AT jagteshwargrewal geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy AT cuilinzhang geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy AT germainembucklouis geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy AT fasiltekolaayele geneticandenvironmentalinfluencesonfetalgrowthvaryduringsensitiveperiodsinpregnancy
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Genetic and Environmental Influences on Fetal Growth Vary during Sensitive Periods in Pregnancy

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