The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

Ovarian cancer remains as one of the most lethal gynecological cancers to date, with major challenges associated with screening, diagnosis and treatment of the disease and an urgent need for new technologies that can meet these challenges. Nanomaterials provide new opportunities in diagnosis and the...

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Autores principales:	Edward Henderson, Gabriel Huynh, Kirsty Wilson, Magdalena Plebanski, Simon Corrie
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ovarian cancer nanoparticles imaging contrast agents molecular imaging intraoperative aids Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3a56f739650a48cc81c8f42031947ace
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spelling	oai:doaj.org-article:3a56f739650a48cc81c8f42031947ace2021-11-25T16:48:58ZThe Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers10.3390/biomedicines91115542227-9059https://doaj.org/article/3a56f739650a48cc81c8f42031947ace2021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1554https://doaj.org/toc/2227-9059Ovarian cancer remains as one of the most lethal gynecological cancers to date, with major challenges associated with screening, diagnosis and treatment of the disease and an urgent need for new technologies that can meet these challenges. Nanomaterials provide new opportunities in diagnosis and therapeutic management of many different types of cancers. In this review, we highlight recent promising developments of nanoparticles designed specifically for the detection or imaging of ovarian cancer that have reached the preclinical stage of development. This includes contrast agents, molecular imaging agents and intraoperative aids that have been designed for integration into standard imaging procedures. While numerous nanoparticle systems have been developed for ovarian cancer detection and imaging, specific design criteria governing nanomaterial targeting, biodistribution and clearance from the peritoneal cavity remain key challenges that need to be overcome before these promising tools can accomplish significant breakthroughs into the clinical setting.Edward HendersonGabriel HuynhKirsty WilsonMagdalena PlebanskiSimon CorrieMDPI AGarticleovarian cancernanoparticlesimagingcontrast agentsmolecular imagingintraoperative aidsBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1554, p 1554 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ovarian cancer nanoparticles imaging contrast agents molecular imaging intraoperative aids Biology (General) QH301-705.5
spellingShingle	ovarian cancer nanoparticles imaging contrast agents molecular imaging intraoperative aids Biology (General) QH301-705.5 Edward Henderson Gabriel Huynh Kirsty Wilson Magdalena Plebanski Simon Corrie The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
description	Ovarian cancer remains as one of the most lethal gynecological cancers to date, with major challenges associated with screening, diagnosis and treatment of the disease and an urgent need for new technologies that can meet these challenges. Nanomaterials provide new opportunities in diagnosis and therapeutic management of many different types of cancers. In this review, we highlight recent promising developments of nanoparticles designed specifically for the detection or imaging of ovarian cancer that have reached the preclinical stage of development. This includes contrast agents, molecular imaging agents and intraoperative aids that have been designed for integration into standard imaging procedures. While numerous nanoparticle systems have been developed for ovarian cancer detection and imaging, specific design criteria governing nanomaterial targeting, biodistribution and clearance from the peritoneal cavity remain key challenges that need to be overcome before these promising tools can accomplish significant breakthroughs into the clinical setting.
format	article
author	Edward Henderson Gabriel Huynh Kirsty Wilson Magdalena Plebanski Simon Corrie
author_facet	Edward Henderson Gabriel Huynh Kirsty Wilson Magdalena Plebanski Simon Corrie
author_sort	Edward Henderson
title	The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
title_short	The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
title_full	The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
title_fullStr	The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
title_full_unstemmed	The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers
title_sort	development of nanoparticles for the detection and imaging of ovarian cancers
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3a56f739650a48cc81c8f42031947ace
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The Development of Nanoparticles for the Detection and Imaging of Ovarian Cancers

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