Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV

Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient...

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Autores principales:	Paulien Vinke, Thomas Koudstaal, Femke Muskens, Annemien van den Bosch, Michiel Balvers, Mieke Poland, Renger F. Witkamp, Klaske van Norren, Karin A. Boomars
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pulmonary hypertension pulmonary arterial hypertension chronic thrombo-embolic pulmonary hypertension vitamin D iron micronutrient deficiencies Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3a57317215684dc0b7ea79e57daa9a53
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spelling	oai:doaj.org-article:3a57317215684dc0b7ea79e57daa9a532021-11-25T18:35:20ZPrevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV10.3390/nu131139232072-6643https://doaj.org/article/3a57317215684dc0b7ea79e57daa9a532021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3923https://doaj.org/toc/2072-6643Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary.Paulien VinkeThomas KoudstaalFemke MuskensAnnemien van den BoschMichiel BalversMieke PolandRenger F. WitkampKlaske van NorrenKarin A. BoomarsMDPI AGarticlepulmonary hypertensionpulmonary arterial hypertensionchronic thrombo-embolic pulmonary hypertensionvitamin Dironmicronutrient deficienciesNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3923, p 3923 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pulmonary hypertension pulmonary arterial hypertension chronic thrombo-embolic pulmonary hypertension vitamin D iron micronutrient deficiencies Nutrition. Foods and food supply TX341-641
spellingShingle	pulmonary hypertension pulmonary arterial hypertension chronic thrombo-embolic pulmonary hypertension vitamin D iron micronutrient deficiencies Nutrition. Foods and food supply TX341-641 Paulien Vinke Thomas Koudstaal Femke Muskens Annemien van den Bosch Michiel Balvers Mieke Poland Renger F. Witkamp Klaske van Norren Karin A. Boomars Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
description	Background: Pulmonary hypertension (PH) is a rare progressive and lethal disease affecting pulmonary arteries and heart function. The disease may compromise the nutritional status of the patient, which impairs their physical performance. This study aimed to determine the prevalence of micronutrient deficiencies in pulmonary arterial hypertension (PAH) and chronic thrombo-embolic pulmonary hypertension (CTEPH) patients. Methods: Eighty-one blood samples from a prospective observational cohort study were analyzed for concentrations of micronutrients and inflammation-related factors. The samples consisted of newly diagnosed (treatment-naive) PAH and CTEPH patients and patients treated for 1.5 years according to ERS/ESC guidelines. Results: In the newly diagnosed group, 42% of PAH patients and 21% of CTEPH patients were iron deficient compared to 29% of PAH patients and 20% of CTEPH patients in the treatment group. Vitamin D deficiency occurred in 42% of the newly diagnosed PAH patients, 71% of the newly diagnosed CTEPH patients, 68% of the treated PAH patients, and 70% of the treated CTEPH patients. Iron levels correlated with the 6 min walking distance (6MWD). Conclusions: Iron and vitamin D deficiencies are highly prevalent in PAH and CTEPH patients, underlining the need for monitoring their status. Studies evaluating the effects of supplementation strategies for iron and vitamin D are necessary.
format	article
author	Paulien Vinke Thomas Koudstaal Femke Muskens Annemien van den Bosch Michiel Balvers Mieke Poland Renger F. Witkamp Klaske van Norren Karin A. Boomars
author_facet	Paulien Vinke Thomas Koudstaal Femke Muskens Annemien van den Bosch Michiel Balvers Mieke Poland Renger F. Witkamp Klaske van Norren Karin A. Boomars
author_sort	Paulien Vinke
title	Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_short	Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_full	Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_fullStr	Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_full_unstemmed	Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV
title_sort	prevalence of micronutrient deficiencies and relationship with clinical and patient-related outcomes in pulmonary hypertension types i and iv
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3a57317215684dc0b7ea79e57daa9a53
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Prevalence of Micronutrient Deficiencies and Relationship with Clinical and Patient-Related Outcomes in Pulmonary Hypertension Types I and IV

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