Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.

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Autores principales:	Yusuke Matsuno, Yuko Atsumi, Atsuhiro Shimizu, Kotoe Katayama, Haruka Fujimori, Mai Hyodo, Yusuke Minakawa, Yoshimichi Nakatsu, Syuzo Kaneko, Ryuji Hamamoto, Teppei Shimamura, Satoru Miyano, Teruhisa Tsuzuki, Fumio Hanaoka, Ken-ichi Yoshioka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a59f10420754664b934a81589710d65
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spelling	oai:doaj.org-article:3a59f10420754664b934a81589710d652021-12-02T17:01:58ZReplication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro10.1038/s41467-019-11760-22041-1723https://doaj.org/article/3a59f10420754664b934a81589710d652019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11760-2https://doaj.org/toc/2041-1723Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.Yusuke MatsunoYuko AtsumiAtsuhiro ShimizuKotoe KatayamaHaruka FujimoriMai HyodoYusuke MinakawaYoshimichi NakatsuSyuzo KanekoRyuji HamamotoTeppei ShimamuraSatoru MiyanoTeruhisa TsuzukiFumio HanaokaKen-ichi YoshiokaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Matsuno Yuko Atsumi Atsuhiro Shimizu Kotoe Katayama Haruka Fujimori Mai Hyodo Yusuke Minakawa Yoshimichi Nakatsu Syuzo Kaneko Ryuji Hamamoto Teppei Shimamura Satoru Miyano Teruhisa Tsuzuki Fumio Hanaoka Ken-ichi Yoshioka Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
description	Mismatch repair (MMR)-deficient cancers are characterized by microsatellite instability (MSI) and hypermutation. Here authors reveal a mechanism by which replication stress induces MSI and associated induction of mutations in vitro.
format	article
author	Yusuke Matsuno Yuko Atsumi Atsuhiro Shimizu Kotoe Katayama Haruka Fujimori Mai Hyodo Yusuke Minakawa Yoshimichi Nakatsu Syuzo Kaneko Ryuji Hamamoto Teppei Shimamura Satoru Miyano Teruhisa Tsuzuki Fumio Hanaoka Ken-ichi Yoshioka
author_facet	Yusuke Matsuno Yuko Atsumi Atsuhiro Shimizu Kotoe Katayama Haruka Fujimori Mai Hyodo Yusuke Minakawa Yoshimichi Nakatsu Syuzo Kaneko Ryuji Hamamoto Teppei Shimamura Satoru Miyano Teruhisa Tsuzuki Fumio Hanaoka Ken-ichi Yoshioka
author_sort	Yusuke Matsuno
title	Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
title_short	Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
title_full	Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
title_fullStr	Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
title_full_unstemmed	Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
title_sort	replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3a59f10420754664b934a81589710d65
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Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

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