Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics

O-GalNAc glycans are essential in many biological and pathological processes, but difficult to access due to their structural complexity and synthetic challenges. Here, the authors report an efficient chemoenzymatic modular assembly strategy to construct structurally diverse O-GalNAc glycans, use th...

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Autores principales:	Shuaishuai Wang, Congcong Chen, Madhusudhan Reddy Gadi, Varma Saikam, Ding Liu, He Zhu, Roni Bollag, Kebin Liu, Xi Chen, Fengshan Wang, Peng George Wang, Peixue Ling, Wanyi Guan, Lei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a64e407ac464a248e796f18a724fe06
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spelling	oai:doaj.org-article:3a64e407ac464a248e796f18a724fe062021-12-02T17:34:29ZChemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics10.1038/s41467-021-23428-x2041-1723https://doaj.org/article/3a64e407ac464a248e796f18a724fe062021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23428-xhttps://doaj.org/toc/2041-1723O-GalNAc glycans are essential in many biological and pathological processes, but difficult to access due to their structural complexity and synthetic challenges. Here, the authors report an efficient chemoenzymatic modular assembly strategy to construct structurally diverse O-GalNAc glycans, use the synthesised glycans to generate a synthetic mucin O-glycan microarray and profile binding specificities of glycan-binding proteins.Shuaishuai WangCongcong ChenMadhusudhan Reddy GadiVarma SaikamDing LiuHe ZhuRoni BollagKebin LiuXi ChenFengshan WangPeng George WangPeixue LingWanyi GuanLei LiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuaishuai Wang Congcong Chen Madhusudhan Reddy Gadi Varma Saikam Ding Liu He Zhu Roni Bollag Kebin Liu Xi Chen Fengshan Wang Peng George Wang Peixue Ling Wanyi Guan Lei Li Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
description	O-GalNAc glycans are essential in many biological and pathological processes, but difficult to access due to their structural complexity and synthetic challenges. Here, the authors report an efficient chemoenzymatic modular assembly strategy to construct structurally diverse O-GalNAc glycans, use the synthesised glycans to generate a synthetic mucin O-glycan microarray and profile binding specificities of glycan-binding proteins.
format	article
author	Shuaishuai Wang Congcong Chen Madhusudhan Reddy Gadi Varma Saikam Ding Liu He Zhu Roni Bollag Kebin Liu Xi Chen Fengshan Wang Peng George Wang Peixue Ling Wanyi Guan Lei Li
author_facet	Shuaishuai Wang Congcong Chen Madhusudhan Reddy Gadi Varma Saikam Ding Liu He Zhu Roni Bollag Kebin Liu Xi Chen Fengshan Wang Peng George Wang Peixue Ling Wanyi Guan Lei Li
author_sort	Shuaishuai Wang
title	Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
title_short	Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
title_full	Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
title_fullStr	Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
title_full_unstemmed	Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics
title_sort	chemoenzymatic modular assembly of o-galnac glycans for functional glycomics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a64e407ac464a248e796f18a724fe06
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Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics

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