Menstrual disorders and their determinants among women with epilepsy

Magdalena Bosak, Agnieszka Słowik, Wojciech Turaj Department of Neurology, Jagiellonian University Medical College, Krakow, Poland Introduction: The purpose of the present study was to assess the prevalence and determinants of menstrual cycle disorders among women with epilepsy. Materials and met...

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Autores principales:	Bosak M, Słowik A, Turaj W
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	menstrual disorders medications side effect women reproductive health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/3a6c9901b94147999e0f9437d8ad5a3b
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spelling	oai:doaj.org-article:3a6c9901b94147999e0f9437d8ad5a3b2021-12-02T08:32:32ZMenstrual disorders and their determinants among women with epilepsy1178-2021https://doaj.org/article/3a6c9901b94147999e0f9437d8ad5a3b2018-10-01T00:00:00Zhttps://www.dovepress.com/menstrual-disorders-and-their-determinants-among-women-with-epilepsy-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Magdalena Bosak, Agnieszka Słowik, Wojciech Turaj Department of Neurology, Jagiellonian University Medical College, Krakow, Poland Introduction: The purpose of the present study was to assess the prevalence and determinants of menstrual cycle disorders among women with epilepsy. Materials and methods: The study included consecutive women with epilepsy who visited a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and its treatment, and data related to reproductive health (regularity of menstrual cycle, number of pregnancies and childbirths), were collected from medical records, seizure diaries, and a dedicated questionnaire. Results: The study involved 271 women with epilepsy. Focal epilepsy was diagnosed in 182 (67.2%) patients; 108 (39.8%) women had rare seizures (<1 per year), and 164 patients (60.5%) were on monotherapy. Menstrual abnormalities were found in 78 patients (28.8%). Independent variables associated with irregular cycle included younger age at onset of epilepsy (OR=0.95 per 1-year increase; P=0.008), current use of clonazepam (OR=5.36; P=0.010), and chronic use of medication(s) other than antiepileptic drug(s) (AEDs; OR=2.48; P=0.003). Childbirth rate was low in our cohort (0.50 per patient); independent predictors of being childless in studied patients included younger age, presence of menstrual disorders, and greater number of currently used AEDs. Conclusion: Menstrual disturbances were present in 28.8% of studied women with epilepsy. Increased prevalence of menstrual abnormalities was associated with epilepsy itself (younger age at onset of epilepsy) and its treatment (ongoing use of clonazepam), as well as with chronic use of medications other than AEDs. Keywords: menstrual disorders, medications, side effect, women, reproductive healthBosak MSłowik ATuraj WDove Medical Pressarticlemenstrual disordersmedicationsside effectwomenreproductive healthNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2657-2664 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	menstrual disorders medications side effect women reproductive health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	menstrual disorders medications side effect women reproductive health Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Bosak M Słowik A Turaj W Menstrual disorders and their determinants among women with epilepsy
description	Magdalena Bosak, Agnieszka Słowik, Wojciech Turaj Department of Neurology, Jagiellonian University Medical College, Krakow, Poland Introduction: The purpose of the present study was to assess the prevalence and determinants of menstrual cycle disorders among women with epilepsy. Materials and methods: The study included consecutive women with epilepsy who visited a university epilepsy clinic. A number of variables, including demographics, characteristics of epilepsy and its treatment, and data related to reproductive health (regularity of menstrual cycle, number of pregnancies and childbirths), were collected from medical records, seizure diaries, and a dedicated questionnaire. Results: The study involved 271 women with epilepsy. Focal epilepsy was diagnosed in 182 (67.2%) patients; 108 (39.8%) women had rare seizures (<1 per year), and 164 patients (60.5%) were on monotherapy. Menstrual abnormalities were found in 78 patients (28.8%). Independent variables associated with irregular cycle included younger age at onset of epilepsy (OR=0.95 per 1-year increase; P=0.008), current use of clonazepam (OR=5.36; P=0.010), and chronic use of medication(s) other than antiepileptic drug(s) (AEDs; OR=2.48; P=0.003). Childbirth rate was low in our cohort (0.50 per patient); independent predictors of being childless in studied patients included younger age, presence of menstrual disorders, and greater number of currently used AEDs. Conclusion: Menstrual disturbances were present in 28.8% of studied women with epilepsy. Increased prevalence of menstrual abnormalities was associated with epilepsy itself (younger age at onset of epilepsy) and its treatment (ongoing use of clonazepam), as well as with chronic use of medications other than AEDs. Keywords: menstrual disorders, medications, side effect, women, reproductive health
format	article
author	Bosak M Słowik A Turaj W
author_facet	Bosak M Słowik A Turaj W
author_sort	Bosak M
title	Menstrual disorders and their determinants among women with epilepsy
title_short	Menstrual disorders and their determinants among women with epilepsy
title_full	Menstrual disorders and their determinants among women with epilepsy
title_fullStr	Menstrual disorders and their determinants among women with epilepsy
title_full_unstemmed	Menstrual disorders and their determinants among women with epilepsy
title_sort	menstrual disorders and their determinants among women with epilepsy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/3a6c9901b94147999e0f9437d8ad5a3b
work_keys_str_mv	AT bosakm menstrualdisordersandtheirdeterminantsamongwomenwithepilepsy AT słowika menstrualdisordersandtheirdeterminantsamongwomenwithepilepsy AT turajw menstrualdisordersandtheirdeterminantsamongwomenwithepilepsy
_version_	1718398477070761984

Menstrual disorders and their determinants among women with epilepsy

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