Link between serum lipid signature and prognostic factors in COVID-19 patients

Abstract Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome....

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Autores principales:	Michele Dei Cas, Sara Ottolenghi, Camillo Morano, Rocco Rinaldo, Gabriella Roda, Davide Chiumello, Stefano Centanni, Michele Samaja, Rita Paroni
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a7088f4b2ed4c51b44fc080701bb9e6
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spelling	oai:doaj.org-article:3a7088f4b2ed4c51b44fc080701bb9e62021-11-08T10:55:46ZLink between serum lipid signature and prognostic factors in COVID-19 patients10.1038/s41598-021-00755-z2045-2322https://doaj.org/article/3a7088f4b2ed4c51b44fc080701bb9e62021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00755-zhttps://doaj.org/toc/2045-2322Abstract Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes.Michele Dei CasSara OttolenghiCamillo MoranoRocco RinaldoGabriella RodaDavide ChiumelloStefano CentanniMichele SamajaRita ParoniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michele Dei Cas Sara Ottolenghi Camillo Morano Rocco Rinaldo Gabriella Roda Davide Chiumello Stefano Centanni Michele Samaja Rita Paroni Link between serum lipid signature and prognostic factors in COVID-19 patients
description	Abstract Although the serum lipidome is markedly affected by COVID-19, two unresolved issues remain: how the severity of the disease affects the level and the composition of serum lipids and whether serum lipidome analysis may identify specific lipids impairment linked to the patients' outcome. Sera from 49 COVID-19 patients were analyzed by untargeted lipidomics. Patients were clustered according to: inflammation (C-reactive protein), hypoxia (Horowitz Index), coagulation state (D-dimer), kidney function (creatinine) and age. COVID-19 patients exhibited remarkable and distinctive dyslipidemia for each prognostic factor associated with reduced defense against oxidative stress. When patients were clustered by outcome (7 days), a peculiar lipidome signature was detected with an overall increase of 29 lipid species, including—among others—four ceramide and three sulfatide species, univocally related to this analysis. Considering the lipids that were affected by all the prognostic factors, we found one sphingomyelin related to inflammation and viral infection of the respiratory tract and two sphingomyelins, that are independently related to patients' age, and they appear as candidate biomarkers to monitor disease progression and severity. Although preliminary and needing validation, this report pioneers the translation of lipidome signatures to link the effects of five critical clinical prognostic factors with the patients' outcomes.
format	article
author	Michele Dei Cas Sara Ottolenghi Camillo Morano Rocco Rinaldo Gabriella Roda Davide Chiumello Stefano Centanni Michele Samaja Rita Paroni
author_facet	Michele Dei Cas Sara Ottolenghi Camillo Morano Rocco Rinaldo Gabriella Roda Davide Chiumello Stefano Centanni Michele Samaja Rita Paroni
author_sort	Michele Dei Cas
title	Link between serum lipid signature and prognostic factors in COVID-19 patients
title_short	Link between serum lipid signature and prognostic factors in COVID-19 patients
title_full	Link between serum lipid signature and prognostic factors in COVID-19 patients
title_fullStr	Link between serum lipid signature and prognostic factors in COVID-19 patients
title_full_unstemmed	Link between serum lipid signature and prognostic factors in COVID-19 patients
title_sort	link between serum lipid signature and prognostic factors in covid-19 patients
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a7088f4b2ed4c51b44fc080701bb9e6
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Link between serum lipid signature and prognostic factors in COVID-19 patients

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