SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER

At the present time, immunosuppressive role of extracellular adenosine in carcinogenesis is actively investigated. Colorectal cancer is one of the most common types of malignant neoplasms in Russia and worldwide, but the role of mediators of adenosine-dependent immunosuppression, such as CD39 (that...

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Autores principales:	G. A. Zhulai, E. K. Oleinik, A. V. Churov, A. A. Romanov, P. N. Kravchenko (Semakova), V. M. Оleinik
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	treg cells cd39 ectonucleotidase a2ar colorectal cancer Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/3a72f4686b8f459eb66656f9a5a6b2fe
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id	oai:doaj.org-article:3a72f4686b8f459eb66656f9a5a6b2fe
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spelling	oai:doaj.org-article:3a72f4686b8f459eb66656f9a5a6b2fe2021-11-18T08:03:46ZSIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER1563-06252313-741X10.15789/1563-0625-2017-1-89-94https://doaj.org/article/3a72f4686b8f459eb66656f9a5a6b2fe2017-01-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1169https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAt the present time, immunosuppressive role of extracellular adenosine in carcinogenesis is actively investigated. Colorectal cancer is one of the most common types of malignant neoplasms in Russia and worldwide, but the role of mediators of adenosine-dependent immunosuppression, such as CD39 (that hydrolyze ATP to adenosine), CD73, A2AR, is not yet clear in patients with colorectal cancer. The levels of specific mRNAs for A2AR, ectonucleotidase CD39, and CD73 genes were assayed in white blood cells of the patients with colorectal cancer. The results have shown that the CD39 mRNA content is increased in the patients with colorectal cancer in the course of the disease progression. Meanwhile, no significant difference for CD73 gene expression was found between the patients and healthy donors. Moreover, an increase in A2AR mRNA expression was noted for the patients with advanced colorectal cancer, thus presuming potential activation of adenosine-A2AR-mediated immunosuppressive mechanism. Furthermore, the CD39 expression on T cells was elevated in parallel to the cancer progression. The most significant changes in CD39 expression were observed for both T helper and Treg cell populations at the late stages of colorectal cancer. Similarly, a direct correlation was revealed between CD39 expression on CD4+CD25+CD127lo/-Treg cells, and changes of A2AR mRNA levels in leukocytes from the cancer patients.G. A. ZhulaiE. K. OleinikA. V. ChurovA. A. RomanovP. N. Kravchenko (Semakova)V. M. ОleinikSPb RAACIarticletreg cellscd39 ectonucleotidasea2arcolorectal cancerImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 1, Pp 89-94 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	treg cells cd39 ectonucleotidase a2ar colorectal cancer Immunologic diseases. Allergy RC581-607
spellingShingle	treg cells cd39 ectonucleotidase a2ar colorectal cancer Immunologic diseases. Allergy RC581-607 G. A. Zhulai E. K. Oleinik A. V. Churov A. A. Romanov P. N. Kravchenko (Semakova) V. M. Оleinik SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
description	At the present time, immunosuppressive role of extracellular adenosine in carcinogenesis is actively investigated. Colorectal cancer is one of the most common types of malignant neoplasms in Russia and worldwide, but the role of mediators of adenosine-dependent immunosuppression, such as CD39 (that hydrolyze ATP to adenosine), CD73, A2AR, is not yet clear in patients with colorectal cancer. The levels of specific mRNAs for A2AR, ectonucleotidase CD39, and CD73 genes were assayed in white blood cells of the patients with colorectal cancer. The results have shown that the CD39 mRNA content is increased in the patients with colorectal cancer in the course of the disease progression. Meanwhile, no significant difference for CD73 gene expression was found between the patients and healthy donors. Moreover, an increase in A2AR mRNA expression was noted for the patients with advanced colorectal cancer, thus presuming potential activation of adenosine-A2AR-mediated immunosuppressive mechanism. Furthermore, the CD39 expression on T cells was elevated in parallel to the cancer progression. The most significant changes in CD39 expression were observed for both T helper and Treg cell populations at the late stages of colorectal cancer. Similarly, a direct correlation was revealed between CD39 expression on CD4+CD25+CD127lo/-Treg cells, and changes of A2AR mRNA levels in leukocytes from the cancer patients.
format	article
author	G. A. Zhulai E. K. Oleinik A. V. Churov A. A. Romanov P. N. Kravchenko (Semakova) V. M. Оleinik
author_facet	G. A. Zhulai E. K. Oleinik A. V. Churov A. A. Romanov P. N. Kravchenko (Semakova) V. M. Оleinik
author_sort	G. A. Zhulai
title	SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
title_short	SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
title_full	SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
title_fullStr	SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
title_full_unstemmed	SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER
title_sort	significance of treg cells for adenosine-mediated immune suppression in colorectal cancer
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/3a72f4686b8f459eb66656f9a5a6b2fe
work_keys_str_mv	AT gazhulai significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer AT ekoleinik significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer AT avchurov significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer AT aaromanov significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer AT pnkravchenkosemakova significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer AT vmoleinik significanceoftregcellsforadenosinemediatedimmunesuppressionincolorectalcancer
_version_	1718422410278993920

SIGNIFICANCE OF Treg CELLS FOR ADENOSINE-MEDIATED IMMUNE SUPPRESSION IN COLORECTAL CANCER

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