Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity
The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and that p300 catalytic activity is decreased in phase-se...
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Nature Portfolio
2021
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oai:doaj.org-article:3a76054979544d3892894768400ab8c12021-12-02T16:13:38ZNuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity10.1038/s41467-021-24950-82041-1723https://doaj.org/article/3a76054979544d3892894768400ab8c12021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24950-8https://doaj.org/toc/2041-1723The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and that p300 catalytic activity is decreased in phase-separated droplets that co-localize with H3K27me3-marked chromatin.Yi ZhangKyle BrownYucong YuZiad IbrahimMohamad ZandianHongwen XuanSteven IngersollThomas LeeChristopher C. EbmeierJiuyang LiuDaniel PanneXiaobing ShiXiaojun RenTatiana G. KutateladzeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yi Zhang Kyle Brown Yucong Yu Ziad Ibrahim Mohamad Zandian Hongwen Xuan Steven Ingersoll Thomas Lee Christopher C. Ebmeier Jiuyang Liu Daniel Panne Xiaobing Shi Xiaojun Ren Tatiana G. Kutateladze Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| description |
The histone acetyltransferase p300 mostly localizes to active chromatin; however, some repressed genes marked with H3K27me3 are also bound by p300. Here the authors show p300 is capable of phase separation, which relies on its catalytic core, and that p300 catalytic activity is decreased in phase-separated droplets that co-localize with H3K27me3-marked chromatin. |
| format |
article |
| author |
Yi Zhang Kyle Brown Yucong Yu Ziad Ibrahim Mohamad Zandian Hongwen Xuan Steven Ingersoll Thomas Lee Christopher C. Ebmeier Jiuyang Liu Daniel Panne Xiaobing Shi Xiaojun Ren Tatiana G. Kutateladze |
| author_facet |
Yi Zhang Kyle Brown Yucong Yu Ziad Ibrahim Mohamad Zandian Hongwen Xuan Steven Ingersoll Thomas Lee Christopher C. Ebmeier Jiuyang Liu Daniel Panne Xiaobing Shi Xiaojun Ren Tatiana G. Kutateladze |
| author_sort |
Yi Zhang |
| title |
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| title_short |
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| title_full |
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| title_fullStr |
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| title_full_unstemmed |
Nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced HAT activity |
| title_sort |
nuclear condensates of p300 formed though the structured catalytic core can act as a storage pool of p300 with reduced hat activity |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/3a76054979544d3892894768400ab8c1 |
| work_keys_str_mv |
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1718384344114921472 |