Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights

Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still...

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Autores principales:	Qing Cai, Zuntai Li, Baosheng Li, Jiayang Jiang, Xiaoyu Li, Weiyan Meng, Shoujun Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	bone tumor osteopathia near-infrared probe diagnosis photoX therapy Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/3a813c4f81ce4dd7a40fb8a442a230cb
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spelling	oai:doaj.org-article:3a813c4f81ce4dd7a40fb8a442a230cb2021-11-18T06:20:36ZPrecise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights2296-418510.3389/fbioe.2021.771153https://doaj.org/article/3a813c4f81ce4dd7a40fb8a442a230cb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.771153/fullhttps://doaj.org/toc/2296-4185Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still lacking. Near-infrared (NIR) bioimaging, especially in the NIR-II (1000-1700 nm) regions, can provide high sensitivity and spatiotemporal resolution bioimaging compared to the conventional radiography. Thus, NIR bioimaging affords intraoperative visualization and imaging-guided surgery, aiming to overcome challenges associated with theranostics of osteopathia and bone tumors. The present review aimed to summarize the latest evidence on the use of NIR probes for the targeting bone imaging. We further highlight the recent advances in bone photoX (X presents thermal, dynamic, and immuno) therapy through NIR probes, in particular combination with other customized therapeutic agents could provide high-efficiency treatment for bone tumors.Qing CaiZuntai LiBaosheng LiJiayang JiangXiaoyu LiWeiyan MengShoujun ZhuFrontiers Media S.A.articlebone tumorosteopathianear-infrared probediagnosisphotoX therapyBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bone tumor osteopathia near-infrared probe diagnosis photoX therapy Biotechnology TP248.13-248.65
spellingShingle	bone tumor osteopathia near-infrared probe diagnosis photoX therapy Biotechnology TP248.13-248.65 Qing Cai Zuntai Li Baosheng Li Jiayang Jiang Xiaoyu Li Weiyan Meng Shoujun Zhu Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
description	Bone is a preferred site for both primary and metastasis tumors. Current diagnosis of osteopathia typically relies on noninvasive skeleton radiography technology. However, due to the limited resolution of ionizing radiation, accurate diagnosis and effective identification impairment areas are still lacking. Near-infrared (NIR) bioimaging, especially in the NIR-II (1000-1700 nm) regions, can provide high sensitivity and spatiotemporal resolution bioimaging compared to the conventional radiography. Thus, NIR bioimaging affords intraoperative visualization and imaging-guided surgery, aiming to overcome challenges associated with theranostics of osteopathia and bone tumors. The present review aimed to summarize the latest evidence on the use of NIR probes for the targeting bone imaging. We further highlight the recent advances in bone photoX (X presents thermal, dynamic, and immuno) therapy through NIR probes, in particular combination with other customized therapeutic agents could provide high-efficiency treatment for bone tumors.
format	article
author	Qing Cai Zuntai Li Baosheng Li Jiayang Jiang Xiaoyu Li Weiyan Meng Shoujun Zhu
author_facet	Qing Cai Zuntai Li Baosheng Li Jiayang Jiang Xiaoyu Li Weiyan Meng Shoujun Zhu
author_sort	Qing Cai
title	Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
title_short	Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
title_full	Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
title_fullStr	Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
title_full_unstemmed	Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights
title_sort	precise diagnosis and therapy of bone cancer using near-infrared lights
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/3a813c4f81ce4dd7a40fb8a442a230cb
work_keys_str_mv	AT qingcai precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT zuntaili precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT baoshengli precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT jiayangjiang precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT xiaoyuli precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT weiyanmeng precisediagnosisandtherapyofbonecancerusingnearinfraredlights AT shoujunzhu precisediagnosisandtherapyofbonecancerusingnearinfraredlights
_version_	1718424471140827136

Precise Diagnosis and Therapy of Bone Cancer Using Near-Infrared Lights

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