Ligneous conjunctivitis in a patient with Crohn′s disease

Ligneous conjunctivitis in a patient with Crohn′s disease

Graciana Fuentes-Páez1, José M Herreras1, M del C Méndez2, MA Saorni1,21Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain and Hospital Universitario de Valladolid, Spain; 2Ocular Patholog...

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Autores principales: Graciana Fuentes-Páez, José M Herreras, M del C Méndez, MA Saorni
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2008
Materias:
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/3a82c9705056461b8b51172894b5054a
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spelling oai:doaj.org-article:3a82c9705056461b8b51172894b5054a2021-12-02T00:42:27ZLigneous conjunctivitis in a patient with Crohn′s disease1177-54671177-5483https://doaj.org/article/3a82c9705056461b8b51172894b5054a2008-03-01T00:00:00Zhttp://www.dovepress.com/ligneous-conjunctivitis-in-a-patient-with-crohnprimes-disease-a371https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Graciana Fuentes-Páez1, José M Herreras1, M del C Méndez2, MA Saorni1,21Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain and Hospital Universitario de Valladolid, Spain; 2Ocular Pathology and Lab Registry “Miguel N. Burnier”, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, SpainObjective: Report the case of a patient with Crohn´s disease and ligneous conjunctivitis.Methods: Interventional case report of a 27-year old female patient, with a 4-year history of Crohn´s disease, was seen for right eye conjunctival ulcer after resolved chemical trauma. Conjunctival biopsy was performed for histopathology, immunofluorescence microscopy, and immunohistochemistry testing.Results: Microbiology tests were negative for bacteria and fungi. PCR was negative for atypical mycobacteria and Herpes. Ocular Crohn´s disease, Whipple disease, and amyloidosis were ruled out. Immunofluorescence microscopy revealed characteristic IgG κ and λ light chain deposits, and fibrin deposition was confirmed through Lendrum´s Martius, Scarlet, and Blue technique. Endogenous plasminogen levels were normal. Recurrent ulcers did not resolve after treatment with infliximab, but only after four surgeries, topical steroids, 1% cyclosporine, heparin (5000 units/ml), and hyaluronidase (1.5 mg/ml). After 9 months of follow-up, nasal symblepharon was observed as sequela.Conclusions: We report the case of a patient with unilateral ligneous conjunctivitis, triggered by chemical injury, and Crohn´s disease.Keywords: Crohn´s disease, immunofluorescence microscopy, ligneous conjunctivitis, plasminogen, ulcerative conjunctivitis Graciana Fuentes-PáezJosé M HerrerasM del C MéndezMA SaorniDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2008, Iss Issue 1, Pp 203-206 (2008)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Graciana Fuentes-Páez
José M Herreras
M del C Méndez
MA Saorni
Ligneous conjunctivitis in a patient with Crohn′s disease
description Graciana Fuentes-Páez1, José M Herreras1, M del C Méndez2, MA Saorni1,21Ocular Immunology and Uveitis Unit, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain and Hospital Universitario de Valladolid, Spain; 2Ocular Pathology and Lab Registry “Miguel N. Burnier”, Institute of Ophthalmobiology (IOBA), University of Valladolid, Valladolid, SpainObjective: Report the case of a patient with Crohn´s disease and ligneous conjunctivitis.Methods: Interventional case report of a 27-year old female patient, with a 4-year history of Crohn´s disease, was seen for right eye conjunctival ulcer after resolved chemical trauma. Conjunctival biopsy was performed for histopathology, immunofluorescence microscopy, and immunohistochemistry testing.Results: Microbiology tests were negative for bacteria and fungi. PCR was negative for atypical mycobacteria and Herpes. Ocular Crohn´s disease, Whipple disease, and amyloidosis were ruled out. Immunofluorescence microscopy revealed characteristic IgG κ and λ light chain deposits, and fibrin deposition was confirmed through Lendrum´s Martius, Scarlet, and Blue technique. Endogenous plasminogen levels were normal. Recurrent ulcers did not resolve after treatment with infliximab, but only after four surgeries, topical steroids, 1% cyclosporine, heparin (5000 units/ml), and hyaluronidase (1.5 mg/ml). After 9 months of follow-up, nasal symblepharon was observed as sequela.Conclusions: We report the case of a patient with unilateral ligneous conjunctivitis, triggered by chemical injury, and Crohn´s disease.Keywords: Crohn´s disease, immunofluorescence microscopy, ligneous conjunctivitis, plasminogen, ulcerative conjunctivitis
format article
author Graciana Fuentes-Páez
José M Herreras
M del C Méndez
MA Saorni
author_facet Graciana Fuentes-Páez
José M Herreras
M del C Méndez
MA Saorni
author_sort Graciana Fuentes-Páez
title Ligneous conjunctivitis in a patient with Crohn′s disease
title_short Ligneous conjunctivitis in a patient with Crohn′s disease
title_full Ligneous conjunctivitis in a patient with Crohn′s disease
title_fullStr Ligneous conjunctivitis in a patient with Crohn′s disease
title_full_unstemmed Ligneous conjunctivitis in a patient with Crohn′s disease
title_sort ligneous conjunctivitis in a patient with crohn′s disease
publisher Dove Medical Press
publishDate 2008
url https://doaj.org/article/3a82c9705056461b8b51172894b5054a
work_keys_str_mv AT gracianafuentespampaacuteez ligneousconjunctivitisinapatientwithcrohnampprimesdisease
AT josampeacutemherreras ligneousconjunctivitisinapatientwithcrohnampprimesdisease
AT mdelcmampeacutendez ligneousconjunctivitisinapatientwithcrohnampprimesdisease
AT masaorni ligneousconjunctivitisinapatientwithcrohnampprimesdisease
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