The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis

Abstract The sensitivity of electrocardiogram (ECG) criteria to detect left ventricular hypertrophy (LVH) is low, especially in women. We determined sex-specific sensitivities of ECG-LVH criteria, and developed new criteria, using cardiovascular magnetic resonance imaging (CMR). Sensitivities of ECG...

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Autores principales:	M. Yldau van der Ende, Tom Hendriks, Yordi van de Vegte, Erik Lipsic, Harold Snieder, Pim van der Harst
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a831547b3be4bf29222a61fd44839c6
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spelling	oai:doaj.org-article:3a831547b3be4bf29222a61fd44839c62021-12-02T11:45:00ZThe Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis10.1038/s41598-021-83137-92045-2322https://doaj.org/article/3a831547b3be4bf29222a61fd44839c62021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83137-9https://doaj.org/toc/2045-2322Abstract The sensitivity of electrocardiogram (ECG) criteria to detect left ventricular hypertrophy (LVH) is low, especially in women. We determined sex-specific sensitivities of ECG-LVH criteria, and developed new criteria, using cardiovascular magnetic resonance imaging (CMR). Sensitivities of ECG-LVH criteria were determined in participants of the UK Biobank (N = 3632). LVH was defined when left ventricular mass was > 95% confidence interval (CI) according to age and sex. In a training cohort (75%, N = 2724), sex-specific ECG-LVH criteria were developed by investigating all possible sums of QRS-amplitudes in all 12 leads, and selecting the sum with the highest pseudo-R2 and area under the curve to detect LVH. Performance was assessed in a validation cohort (25%, N = 908), and association with blood pressure change was investigated in an independent cohort. Sensitivities of ECG-LVH criteria were low, especially in women. Newly developed Groningen-LVH criterion for women (QV2 + RI + RV5 + RV6 + SV2 + SV4 + SV5 + SV6) outperformed all ECG-LVH criteria with a sensitivity of 42% (95% CI 35–49%). In men, newly developed criterion ((RI + RV5 + SII + SV2 + SV6) × QRS duration) was equally sensitive as 12-lead sum with a sensitivity of 44% (95% CI 37–51%) and outperformed the other criteria. In an independent cohort, the Groningen-LVH criteria were strongest associated with change in systolic blood pressure. Our proposed CMR sex-specific Groningen-LVH criteria improve the sensitivity to detect LVH, especially in women. Further validation and its association with clinical outcomes is warranted.M. Yldau van der EndeTom HendriksYordi van de VegteErik LipsicHarold SniederPim van der HarstNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Yldau van der Ende Tom Hendriks Yordi van de Vegte Erik Lipsic Harold Snieder Pim van der Harst The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
description	Abstract The sensitivity of electrocardiogram (ECG) criteria to detect left ventricular hypertrophy (LVH) is low, especially in women. We determined sex-specific sensitivities of ECG-LVH criteria, and developed new criteria, using cardiovascular magnetic resonance imaging (CMR). Sensitivities of ECG-LVH criteria were determined in participants of the UK Biobank (N = 3632). LVH was defined when left ventricular mass was > 95% confidence interval (CI) according to age and sex. In a training cohort (75%, N = 2724), sex-specific ECG-LVH criteria were developed by investigating all possible sums of QRS-amplitudes in all 12 leads, and selecting the sum with the highest pseudo-R2 and area under the curve to detect LVH. Performance was assessed in a validation cohort (25%, N = 908), and association with blood pressure change was investigated in an independent cohort. Sensitivities of ECG-LVH criteria were low, especially in women. Newly developed Groningen-LVH criterion for women (QV2 + RI + RV5 + RV6 + SV2 + SV4 + SV5 + SV6) outperformed all ECG-LVH criteria with a sensitivity of 42% (95% CI 35–49%). In men, newly developed criterion ((RI + RV5 + SII + SV2 + SV6) × QRS duration) was equally sensitive as 12-lead sum with a sensitivity of 44% (95% CI 37–51%) and outperformed the other criteria. In an independent cohort, the Groningen-LVH criteria were strongest associated with change in systolic blood pressure. Our proposed CMR sex-specific Groningen-LVH criteria improve the sensitivity to detect LVH, especially in women. Further validation and its association with clinical outcomes is warranted.
format	article
author	M. Yldau van der Ende Tom Hendriks Yordi van de Vegte Erik Lipsic Harold Snieder Pim van der Harst
author_facet	M. Yldau van der Ende Tom Hendriks Yordi van de Vegte Erik Lipsic Harold Snieder Pim van der Harst
author_sort	M. Yldau van der Ende
title	The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
title_short	The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
title_full	The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
title_fullStr	The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
title_full_unstemmed	The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
title_sort	groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a831547b3be4bf29222a61fd44839c6
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The Groningen electrocardiographic criteria for left ventricular hypertrophy: a sex-specific analysis

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