Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene

Quercetin (QN) is a naturally occurring phenolic compound found largely in vegetables and fruits. Lycopene (LY) is yet another natural phytocompound, found abundantly in red-colored fruits and vegetables. Both have been reported to have beneficial activities in humans. In this study, we document in...

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Autores principales:	LIJUAN Chen, XIAOLI Wu, WEIWEI Wang, XIA Wang, Jianhua Ma
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	cardioprotection phytocompounds quercetin lycopene isoproterenol Medicine R
Acceso en línea:	https://doaj.org/article/3a8b4d6fc704441f9c146aa86ad521fa
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spelling	oai:doaj.org-article:3a8b4d6fc704441f9c146aa86ad521fa2021-11-26T11:19:48ZQuercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene1993-28201819-635710.1080/19932820.2021.1943924https://doaj.org/article/3a8b4d6fc704441f9c146aa86ad521fa2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19932820.2021.1943924https://doaj.org/toc/1993-2820https://doaj.org/toc/1819-6357Quercetin (QN) is a naturally occurring phenolic compound found largely in vegetables and fruits. Lycopene (LY) is yet another natural phytocompound, found abundantly in red-colored fruits and vegetables. Both have been reported to have beneficial activities in humans. In this study, we document in vivo experimental model for isoproterenol (ISO) cardiac injury toxicity in Sprague-Dawley (SD) rats and treatment with a combined optimized concentration of quercetin and lycopene (QL). Male SD rats of different groups were treated with QL (80 mg/kg QN and 3 mg/kg LY together p.o.) for 10 days with ISO administration (100 mg/kg i.p.) on days 7 and 8. After experimental period, CK-MB, TROP, AST, ALT, LDH, GST, GPx, CAT, SOD, Vit.E, Vit. C, GSH, GSSG and MDA were estimated. SD rats administered with ISO showed an obvious rise in the serum marker enzyme levels and tissue oxidative stress markers (MDA and GSSG). Furthermore, marked reductions in the body weight and increases enzymic and non-enzymic antioxidant levels were noticed. Histological features of the heart also indicated a disruption in the cardiac myofibrils structure of ISO-intoxicated rats. Also, quantitative PCR analysis revealed an involvement of antioxidant and related pathway genes such as Nrf2, HO-1, NQO1, GSTµ, SOD1, SOD2, CAT and BCl-2 genes. QL pretreatment prevented all these adverse effects of ISO cardiotoxicity and significantly reduced the myocardial damage. Decrease in oxidative stress was observed, possibly through alterations in the expression levels of enzymic antioxidant genes (GSTµ, SOD1, SOD2 and CAT). In general, QL exert a strong protective effect through the modulations in enzymic antioxidant activity and associated molecular pathways-regulating effect in cardiovascular disease.LIJUAN ChenXIAOLI WuWEIWEI WangXIA WangJianhua MaTaylor & Francis GrouparticlecardioprotectionphytocompoundsquercetinlycopeneisoproterenolMedicineRENLibyan Journal of Medicine, Vol 16, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardioprotection phytocompounds quercetin lycopene isoproterenol Medicine R
spellingShingle	cardioprotection phytocompounds quercetin lycopene isoproterenol Medicine R LIJUAN Chen XIAOLI Wu WEIWEI Wang XIA Wang Jianhua Ma Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
description	Quercetin (QN) is a naturally occurring phenolic compound found largely in vegetables and fruits. Lycopene (LY) is yet another natural phytocompound, found abundantly in red-colored fruits and vegetables. Both have been reported to have beneficial activities in humans. In this study, we document in vivo experimental model for isoproterenol (ISO) cardiac injury toxicity in Sprague-Dawley (SD) rats and treatment with a combined optimized concentration of quercetin and lycopene (QL). Male SD rats of different groups were treated with QL (80 mg/kg QN and 3 mg/kg LY together p.o.) for 10 days with ISO administration (100 mg/kg i.p.) on days 7 and 8. After experimental period, CK-MB, TROP, AST, ALT, LDH, GST, GPx, CAT, SOD, Vit.E, Vit. C, GSH, GSSG and MDA were estimated. SD rats administered with ISO showed an obvious rise in the serum marker enzyme levels and tissue oxidative stress markers (MDA and GSSG). Furthermore, marked reductions in the body weight and increases enzymic and non-enzymic antioxidant levels were noticed. Histological features of the heart also indicated a disruption in the cardiac myofibrils structure of ISO-intoxicated rats. Also, quantitative PCR analysis revealed an involvement of antioxidant and related pathway genes such as Nrf2, HO-1, NQO1, GSTµ, SOD1, SOD2, CAT and BCl-2 genes. QL pretreatment prevented all these adverse effects of ISO cardiotoxicity and significantly reduced the myocardial damage. Decrease in oxidative stress was observed, possibly through alterations in the expression levels of enzymic antioxidant genes (GSTµ, SOD1, SOD2 and CAT). In general, QL exert a strong protective effect through the modulations in enzymic antioxidant activity and associated molecular pathways-regulating effect in cardiovascular disease.
format	article
author	LIJUAN Chen XIAOLI Wu WEIWEI Wang XIA Wang Jianhua Ma
author_facet	LIJUAN Chen XIAOLI Wu WEIWEI Wang XIA Wang Jianhua Ma
author_sort	LIJUAN Chen
title	Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
title_short	Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
title_full	Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
title_fullStr	Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
title_full_unstemmed	Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene
title_sort	quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: cardioprotection by quercetin & lycopene
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/3a8b4d6fc704441f9c146aa86ad521fa
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_version_	1718409461398241280

Quercetin with lycopene modulates enzymic antioxidant genes pathway in isoproterenol cardiotoxicity in rats: Cardioprotection by quercetin & lycopene

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