Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease

Abstract Coronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker...

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Autores principales:	Yizhou Wen, Xianmin Wang, Yonghong Guo, Mei Jin, Jimei Xi, Tingting Chen, Kun Shi, Yaheng Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a8ca22d80004463a599ca1753bef42d
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spelling	oai:doaj.org-article:3a8ca22d80004463a599ca1753bef42d2021-12-02T14:30:46ZPredictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease10.1038/s41598-021-87704-y2045-2322https://doaj.org/article/3a8ca22d80004463a599ca1753bef42d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87704-yhttps://doaj.org/toc/2045-2322Abstract Coronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD.Yizhou WenXianmin WangYonghong GuoMei JinJimei XiTingting ChenKun ShiYaheng LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yizhou Wen Xianmin Wang Yonghong Guo Mei Jin Jimei Xi Tingting Chen Kun Shi Yaheng Lu Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
description	Abstract Coronary artery abnormalities (CAAs) are a severe complication of Kawasaki disease (KD) that may lead to cardiovascular events. Given the evidence that brachial artery flow-mediated dilation (FMD) decreases in children after the onset of KD, we hypothesized that it could be an early marker of CAA development in the acute stage and investigated its relationship with variation in the coronary artery diameter. A total of 326 sex- and age-matched children were enrolled, including 120 with KD, 109 febrile children and 97 healthy controls. In this study, FMD was significantly decreased in the KD group compared with the febrile and healthy groups. FMD was lower in the CAA group than in the no coronary artery abnormality group. The comparison of FMD showed an obvious difference among the CAA subgroups. The FMD in the coronary aneurysm (CA) group showed a strong negative correlation with the pretreatment maximum coronary artery Z-score (preZmax). While preZmax was 2.5, the receiver operating characteristic curve indicated an optimal cutoff point of 3.44% for FMD. FMD ≤ 3.44% could be considered as a signal of coronary lesions in acute stage of KD.
format	article
author	Yizhou Wen Xianmin Wang Yonghong Guo Mei Jin Jimei Xi Tingting Chen Kun Shi Yaheng Lu
author_facet	Yizhou Wen Xianmin Wang Yonghong Guo Mei Jin Jimei Xi Tingting Chen Kun Shi Yaheng Lu
author_sort	Yizhou Wen
title	Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
title_short	Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
title_full	Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
title_fullStr	Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
title_full_unstemmed	Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease
title_sort	predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of kawasaki disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a8ca22d80004463a599ca1753bef42d
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Predictive value of brachial artery flow-mediated dilation on coronary artery abnormality in acute stage of Kawasaki disease

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