Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition

Marwa Ahmed Sallam, Hala Mahmoud Helal, Sana Mohamed Mortada Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance the...

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Autores principales:	Sallam MA, Helal HM, Mortada SM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Allergic rhinitis nanocapsules triamcinolone acetonide nasal mucosa nasal deposition Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/3a8d3b17f49d47e1ae97a17328eb68a0
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spelling	oai:doaj.org-article:3a8d3b17f49d47e1ae97a17328eb68a02021-12-02T00:43:23ZRationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition1178-2013https://doaj.org/article/3a8d3b17f49d47e1ae97a17328eb68a02016-05-01T00:00:00Zhttps://www.dovepress.com/rationally-designed-nanocarriers-for-intranasal-therapy-of-allergic-rh-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Marwa Ahmed Sallam, Hala Mahmoud Helal, Sana Mohamed Mortada Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs), lipid nanocarriers such as nanoemulsion (NE), and nanostructured lipid carriers (NLCs). The elaborated nanocarriers were compared with TA suspension and the commercially available suspension “Nasacort®”. The study revealed that NC provided the highest mucosal retention, as 46.14%±0.048% of the TA initial dose was retained after 24 hours, while showing the least permeation through the nasal mucosa. On the other hand, for TA suspension and Nasacort®, the mucosal retention did not exceed 23.5%±0.047% of the initial dose after 24 hours. For NE and NLC, values of mucosal retention were 19.4%±0.041% and 10.97%±0.13%, respectively. NC also showed lower mucosal irritation and superior stability compared with NE. The in vivo nasal deposition study demonstrated that NC maintained drug in its site of action (nasal cavity mucosa) for the longest period of time. The elaborated polymeric oil core NCs are efficient carriers for the administration of nasally acting TA as it produced the least permeation results, thus decreasing systemic absorption of TA. Although NCs have been administered via various routes, this is the first study to implement the polymeric oil core NC as an efficient carrier for localized nasal drug delivery. Keywords: allergic rhinitis, nanocapsules, triamcinolone acetonide, nasal mucosa, nasal depositionSallam MAHelal HMMortada SMDove Medical PressarticleAllergic rhinitisnanocapsulestriamcinolone acetonidenasal mucosanasal depositionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2345-2357 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Allergic rhinitis nanocapsules triamcinolone acetonide nasal mucosa nasal deposition Medicine (General) R5-920
spellingShingle	Allergic rhinitis nanocapsules triamcinolone acetonide nasal mucosa nasal deposition Medicine (General) R5-920 Sallam MA Helal HM Mortada SM Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
description	Marwa Ahmed Sallam, Hala Mahmoud Helal, Sana Mohamed Mortada Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The aim of this study is to develop a locally acting nasal delivery system of triamcinolone acetonide (TA) for the maintenance therapy of allergic rhinitis. The effect of encapsulating TA in different nanocarriers on its mucosal permeation and retention as well as in vivo nasal deposition has been studied. A comparative study was established between polymeric oil core nanocapsules (NCs), lipid nanocarriers such as nanoemulsion (NE), and nanostructured lipid carriers (NLCs). The elaborated nanocarriers were compared with TA suspension and the commercially available suspension “Nasacort®”. The study revealed that NC provided the highest mucosal retention, as 46.14%±0.048% of the TA initial dose was retained after 24 hours, while showing the least permeation through the nasal mucosa. On the other hand, for TA suspension and Nasacort®, the mucosal retention did not exceed 23.5%±0.047% of the initial dose after 24 hours. For NE and NLC, values of mucosal retention were 19.4%±0.041% and 10.97%±0.13%, respectively. NC also showed lower mucosal irritation and superior stability compared with NE. The in vivo nasal deposition study demonstrated that NC maintained drug in its site of action (nasal cavity mucosa) for the longest period of time. The elaborated polymeric oil core NCs are efficient carriers for the administration of nasally acting TA as it produced the least permeation results, thus decreasing systemic absorption of TA. Although NCs have been administered via various routes, this is the first study to implement the polymeric oil core NC as an efficient carrier for localized nasal drug delivery. Keywords: allergic rhinitis, nanocapsules, triamcinolone acetonide, nasal mucosa, nasal deposition
format	article
author	Sallam MA Helal HM Mortada SM
author_facet	Sallam MA Helal HM Mortada SM
author_sort	Sallam MA
title	Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
title_short	Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
title_full	Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
title_fullStr	Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
title_full_unstemmed	Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
title_sort	rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/3a8d3b17f49d47e1ae97a17328eb68a0
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Rationally designed nanocarriers for intranasal therapy of allergic rhinitis: influence of carrier type on in vivo nasal deposition

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