Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability...

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Autores principales: Yolanda Arias-Córdova, Jorge Luis Ble-Castillo, Carlos García-Vázquez, Viridiana Olvera-Hernández, Meztli Ramos-García, Adrián Navarrete-Cortes, Guadalupe Jiménez-Domínguez, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, Mirian Carolina Martínez-López, José D. Méndez
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/3a8fb7d8830f4b9aaf2926b50b19e794
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Sumario:We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28–65 years, BMI ≥ 25 kg/m<sup>2</sup>, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 (<i>p</i> < 0.05). CONGA, GRADE, and J-index values were higher in HMS compared with DMS only at day 4 (<i>p</i> < 0.05). Yet, NBS intake provoked a reduction in fasting glycemia changes from baseline compared with DMS (<i>p</i> = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors.