Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability...

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Autores principales:	Yolanda Arias-Córdova, Jorge Luis Ble-Castillo, Carlos García-Vázquez, Viridiana Olvera-Hernández, Meztli Ramos-García, Adrián Navarrete-Cortes, Guadalupe Jiménez-Domínguez, Isela Esther Juárez-Rojop, Carlos Alfonso Tovilla-Zárate, Mirian Carolina Martínez-López, José D. Méndez
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	resistant starch banana glycemic variability glycemic control type 2 diabetes continuous glucose monitoring Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/3a8fb7d8830f4b9aaf2926b50b19e794
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spelling	oai:doaj.org-article:3a8fb7d8830f4b9aaf2926b50b19e7942021-11-25T18:36:23ZResistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study10.3390/nu131140522072-6643https://doaj.org/article/3a8fb7d8830f4b9aaf2926b50b19e7942021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4052https://doaj.org/toc/2072-6643We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28–65 years, BMI ≥ 25 kg/m<sup>2</sup>, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 (<i>p</i> < 0.05). CONGA, GRADE, and J-index values were higher in HMS compared with DMS only at day 4 (<i>p</i> < 0.05). Yet, NBS intake provoked a reduction in fasting glycemia changes from baseline compared with DMS (<i>p</i> = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors.Yolanda Arias-CórdovaJorge Luis Ble-CastilloCarlos García-VázquezViridiana Olvera-HernándezMeztli Ramos-GarcíaAdrián Navarrete-CortesGuadalupe Jiménez-DomínguezIsela Esther Juárez-RojopCarlos Alfonso Tovilla-ZárateMirian Carolina Martínez-LópezJosé D. MéndezMDPI AGarticleresistant starchbananaglycemic variabilityglycemic controltype 2 diabetescontinuous glucose monitoringNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4052, p 4052 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	resistant starch banana glycemic variability glycemic control type 2 diabetes continuous glucose monitoring Nutrition. Foods and food supply TX341-641
spellingShingle	resistant starch banana glycemic variability glycemic control type 2 diabetes continuous glucose monitoring Nutrition. Foods and food supply TX341-641 Yolanda Arias-Córdova Jorge Luis Ble-Castillo Carlos García-Vázquez Viridiana Olvera-Hernández Meztli Ramos-García Adrián Navarrete-Cortes Guadalupe Jiménez-Domínguez Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate Mirian Carolina Martínez-López José D. Méndez Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
description	We previously observed beneficial effects of native banana starch (NBS) with a high resistant starch (RS) content on glycemic response in lean and obese participants. Here, we aimed to determine the effects of NBS and high-amylose maize starch (HMS) on glycemic control (GC) and glycemic variability (GV) in patients with type 2 diabetes (T2D) when treatments were matched for digestible starch content. In a randomized, crossover study, continuous glucose monitoring (CGM) was performed in 17 participants (aged 28–65 years, BMI ≥ 25 kg/m<sup>2</sup>, both genders) consuming HMS, NBS, or digestible maize starch (DMS) for 4 days. HMS and NBS induced an increase in 24 h mean blood glucose during days 2 to 4 (<i>p</i> < 0.05). CONGA, GRADE, and J-index values were higher in HMS compared with DMS only at day 4 (<i>p</i> < 0.05). Yet, NBS intake provoked a reduction in fasting glycemia changes from baseline compared with DMS (<i>p</i> = 0.0074). In conclusion, under the experimental conditions, RS from two sources did not improve GC or GV. Future longer studies are needed to determine whether these findings were affected by a different baseline microbiota or other environmental factors.
format	article
author	Yolanda Arias-Córdova Jorge Luis Ble-Castillo Carlos García-Vázquez Viridiana Olvera-Hernández Meztli Ramos-García Adrián Navarrete-Cortes Guadalupe Jiménez-Domínguez Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate Mirian Carolina Martínez-López José D. Méndez
author_facet	Yolanda Arias-Córdova Jorge Luis Ble-Castillo Carlos García-Vázquez Viridiana Olvera-Hernández Meztli Ramos-García Adrián Navarrete-Cortes Guadalupe Jiménez-Domínguez Isela Esther Juárez-Rojop Carlos Alfonso Tovilla-Zárate Mirian Carolina Martínez-López José D. Méndez
author_sort	Yolanda Arias-Córdova
title	Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
title_short	Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
title_full	Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
title_fullStr	Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
title_full_unstemmed	Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study
title_sort	resistant starch consumption effects on glycemic control and glycemic variability in patients with type 2 diabetes: a randomized crossover study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3a8fb7d8830f4b9aaf2926b50b19e794
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Resistant Starch Consumption Effects on Glycemic Control and Glycemic Variability in Patients with Type 2 Diabetes: A Randomized Crossover Study

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