Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold

Abstract Regenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of...

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Autores principales:	Selvakumar Kritika, V. Sujatha, N. Srinivasan, Senthil Kumar Renganathan, Sekar Mahalaxmi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a8fbd5381d348ad80b9fabfe88990ee
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spelling	oai:doaj.org-article:3a8fbd5381d348ad80b9fabfe88990ee2021-12-02T18:18:51ZProspective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold10.1038/s41598-021-93236-22045-2322https://doaj.org/article/3a8fbd5381d348ad80b9fabfe88990ee2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93236-2https://doaj.org/toc/2045-2322Abstract Regenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of non-vital immature permanent maxillary central incisors using PRF with a follow-up for 2 yrs. 19 patients in the age group of 9–25 yrs with immature, non-vital permanent maxillary central incisors (n = 23) with/without signs and/or symptoms of periapical pathosis and open apex were included in this study. In the first appointment, access opening, canal disinfection and triple antibiotic paste placement were done. In the subsequent visit, PRF was prepared and placed inside the canal. Access was sealed with Mineral trioxide aggregate plug and composite. The patient was reviewed up to 24 mths. The mean difference was statistically analyzed using Friedman test followed by Dunn post hoc test and adjusted by Bonferroni correction (p < 0.05). As per AAE guidelines, the primary and secondary goals were achieved. A significant (p < 0.001) gradual increase in the root length, thickness of dentinal walls and decrease in apical diameter were observed. Within the limitations of this study, PRF placement was clinically and radiographically effective in inducing regeneration of non-vital immature permanent teeth.Selvakumar KritikaV. SujathaN. SrinivasanSenthil Kumar RenganathanSekar MahalaxmiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Selvakumar Kritika V. Sujatha N. Srinivasan Senthil Kumar Renganathan Sekar Mahalaxmi Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
description	Abstract Regenerative endodontic procedures have gained momentum as a treatment modality of young immature permanent teeth. Literature reports reveal that platelet-rich fibrin (PRF) stimulates growth factors and induces regeneration. This study was undertaken to assess the regenerative potential of non-vital immature permanent maxillary central incisors using PRF with a follow-up for 2 yrs. 19 patients in the age group of 9–25 yrs with immature, non-vital permanent maxillary central incisors (n = 23) with/without signs and/or symptoms of periapical pathosis and open apex were included in this study. In the first appointment, access opening, canal disinfection and triple antibiotic paste placement were done. In the subsequent visit, PRF was prepared and placed inside the canal. Access was sealed with Mineral trioxide aggregate plug and composite. The patient was reviewed up to 24 mths. The mean difference was statistically analyzed using Friedman test followed by Dunn post hoc test and adjusted by Bonferroni correction (p < 0.05). As per AAE guidelines, the primary and secondary goals were achieved. A significant (p < 0.001) gradual increase in the root length, thickness of dentinal walls and decrease in apical diameter were observed. Within the limitations of this study, PRF placement was clinically and radiographically effective in inducing regeneration of non-vital immature permanent teeth.
format	article
author	Selvakumar Kritika V. Sujatha N. Srinivasan Senthil Kumar Renganathan Sekar Mahalaxmi
author_facet	Selvakumar Kritika V. Sujatha N. Srinivasan Senthil Kumar Renganathan Sekar Mahalaxmi
author_sort	Selvakumar Kritika
title	Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
title_short	Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
title_full	Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
title_fullStr	Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
title_full_unstemmed	Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
title_sort	prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3a8fbd5381d348ad80b9fabfe88990ee
work_keys_str_mv	AT selvakumarkritika prospectivecohortstudyofregenerativepotentialofnonvitalimmaturepermanentmaxillarycentralincisorsusingplateletrichfibrinscaffold AT vsujatha prospectivecohortstudyofregenerativepotentialofnonvitalimmaturepermanentmaxillarycentralincisorsusingplateletrichfibrinscaffold AT nsrinivasan prospectivecohortstudyofregenerativepotentialofnonvitalimmaturepermanentmaxillarycentralincisorsusingplateletrichfibrinscaffold AT senthilkumarrenganathan prospectivecohortstudyofregenerativepotentialofnonvitalimmaturepermanentmaxillarycentralincisorsusingplateletrichfibrinscaffold AT sekarmahalaxmi prospectivecohortstudyofregenerativepotentialofnonvitalimmaturepermanentmaxillarycentralincisorsusingplateletrichfibrinscaffold
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Prospective cohort study of regenerative potential of non vital immature permanent maxillary central incisors using platelet rich fibrin scaffold

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