Defining obesity hypoventilation syndrome

With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pi...

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Autores principales:	Neeraj M. Shah, Sonia Shrimanker, Georgios Kaltsakas
Formato:	article
Lenguaje:	EN
Publicado:	European Respiratory Society 2021
Materias:	Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/3a91502560e746db9b16b78829f742bd
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spelling	oai:doaj.org-article:3a91502560e746db9b16b78829f742bd2021-11-24T07:45:28ZDefining obesity hypoventilation syndrome1810-68382073-473510.1183/20734735.0089-2021https://doaj.org/article/3a91502560e746db9b16b78829f742bd2021-09-01T00:00:00Zhttp://breathe.ersjournals.com/content/17/3/210089.fullhttps://doaj.org/toc/1810-6838https://doaj.org/toc/2073-4735With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion. Educational aims To provide an overview of the historical basis of the definition of obesity hypoventilation syndrome. To explain the rationale for the current definition of obesity hypoventilation syndrome. To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.Neeraj M. ShahSonia ShrimankerGeorgios KaltsakasEuropean Respiratory SocietyarticleDiseases of the respiratory systemRC705-779ENBreathe, Vol 17, Iss 3 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the respiratory system RC705-779
spellingShingle	Diseases of the respiratory system RC705-779 Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas Defining obesity hypoventilation syndrome
description	With increasing prevalence of obesity, the substantial contribution of obesity hypoventilation syndrome (OHS) to morbidity and mortality is likely to increase. It is therefore crucial that the condition has a clear definition to allow timely identification of patients. OHS was first described as “Pickwickian syndrome” in the 1950s; in subsequent decades, case reports did not clearly delineate between patients suffering from OHS and those suffering from obstructive sleep apnoea. In 1999, the American Academy of Sleep Medicine published a guideline that delineated the cause of daytime hypercapnia as either predominantly upper airway or predominantly hypoventilation. This was the first formal definition of OHS as the presence of daytime alveolar hypoventilation (arterial carbon dioxide tension >45 mmHg) in patients with body mass index >30 kg·m−2 in the absence of other causes of hypoventilation. This definition is reflected in the most recent guidelines published on OHS. Recent developments in defining OHS include proposed classification systems of severity and demonstrating the value of using serum bicarbonate to exclude OHS in patients with a low index of suspicion. Educational aims To provide an overview of the historical basis of the definition of obesity hypoventilation syndrome. To explain the rationale for the current definition of obesity hypoventilation syndrome. To demonstrate areas that need further investigation in defining obesity hypoventilation syndrome.
format	article
author	Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas
author_facet	Neeraj M. Shah Sonia Shrimanker Georgios Kaltsakas
author_sort	Neeraj M. Shah
title	Defining obesity hypoventilation syndrome
title_short	Defining obesity hypoventilation syndrome
title_full	Defining obesity hypoventilation syndrome
title_fullStr	Defining obesity hypoventilation syndrome
title_full_unstemmed	Defining obesity hypoventilation syndrome
title_sort	defining obesity hypoventilation syndrome
publisher	European Respiratory Society
publishDate	2021
url	https://doaj.org/article/3a91502560e746db9b16b78829f742bd
work_keys_str_mv	AT neerajmshah definingobesityhypoventilationsyndrome AT soniashrimanker definingobesityhypoventilationsyndrome AT georgioskaltsakas definingobesityhypoventilationsyndrome
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Defining obesity hypoventilation syndrome

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