Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations

Abstract Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to p...

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Autores principales:	Anais Bompard, Dari F. Da, Rakiswendé S. Yerbanga, Sumi Biswas, Melissa Kapulu, Teun Bousema, Thierry Lefèvre, Anna Cohuet, Thomas S. Churcher
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a91c7a83f314d7398ec266842b1ca4e
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spelling	oai:doaj.org-article:3a91c7a83f314d7398ec266842b1ca4e2021-12-02T11:53:12ZEvaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations10.1038/s41598-017-06130-12045-2322https://doaj.org/article/3a91c7a83f314d7398ec266842b1ca4e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06130-1https://doaj.org/toc/2045-2322Abstract Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. A mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers required to halt transmission in different settings. The increased efficacy with diminishing parasite exposure indicates that the efficacy of vaccines targeting either Pfs25 or Pfs230 may increase as malaria transmission declines. This has important implications for late-stage candidate selection and assessing how they can support the drive for malaria elimination.Anais BompardDari F. DaRakiswendé S. YerbangaSumi BiswasMelissa KapuluTeun BousemaThierry LefèvreAnna CohuetThomas S. ChurcherNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anais Bompard Dari F. Da Rakiswendé S. Yerbanga Sumi Biswas Melissa Kapulu Teun Bousema Thierry Lefèvre Anna Cohuet Thomas S. Churcher Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
description	Abstract Transmission blocking vaccines (TBV) which aim to control malaria by inhibiting human-to-mosquito transmission show considerable promise though their utility against naturally circulating parasites remains unknown. The efficacy of two lead candidates targeting Pfs25 and Pfs230 antigens to prevent onwards transmission of naturally occurring parasites to a local mosquito strain is assessed using direct membrane feeding assays and murine antibodies in Burkina Faso. The transmission blocking activity of both candidates depends on the level of parasite exposure (as assessed by the mean number of oocysts in control mosquitoes) and antibody titers. A mathematical framework is devised to allow the efficacy of different candidates to be directly compared and determine the minimal antibody titers required to halt transmission in different settings. The increased efficacy with diminishing parasite exposure indicates that the efficacy of vaccines targeting either Pfs25 or Pfs230 may increase as malaria transmission declines. This has important implications for late-stage candidate selection and assessing how they can support the drive for malaria elimination.
format	article
author	Anais Bompard Dari F. Da Rakiswendé S. Yerbanga Sumi Biswas Melissa Kapulu Teun Bousema Thierry Lefèvre Anna Cohuet Thomas S. Churcher
author_facet	Anais Bompard Dari F. Da Rakiswendé S. Yerbanga Sumi Biswas Melissa Kapulu Teun Bousema Thierry Lefèvre Anna Cohuet Thomas S. Churcher
author_sort	Anais Bompard
title	Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_short	Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_full	Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_fullStr	Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_full_unstemmed	Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
title_sort	evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3a91c7a83f314d7398ec266842b1ca4e
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Evaluation of two lead malaria transmission blocking vaccine candidate antibodies in natural parasite-vector combinations

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