CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

Our understanding on how CAFs can be activated to support tumour progression is still limited. Here, the authors demonstrate that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Cell suppression and tumour growth.

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Detalles Bibliográficos
Autores principales:	Miao Yu, Gang Guo, Lei Huang, Libin Deng, Chang-Sheng Chang, Bhagelu R. Achyut, Madison Canning, Ningchun Xu, Ali S. Arbab, Roni J. Bollag, Paulo C. Rodriguez, Andrew L. Mellor, Huidong Shi, David H. Munn, Yan Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3a939ed9e1ba46adb3d1e889423e5b4d
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spelling	oai:doaj.org-article:3a939ed9e1ba46adb3d1e889423e5b4d2021-12-02T15:39:26ZCD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint10.1038/s41467-019-14060-x2041-1723https://doaj.org/article/3a939ed9e1ba46adb3d1e889423e5b4d2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14060-xhttps://doaj.org/toc/2041-1723Our understanding on how CAFs can be activated to support tumour progression is still limited. Here, the authors demonstrate that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Cell suppression and tumour growth.Miao YuGang GuoLei HuangLibin DengChang-Sheng ChangBhagelu R. AchyutMadison CanningNingchun XuAli S. ArbabRoni J. BollagPaulo C. RodriguezAndrew L. MellorHuidong ShiDavid H. MunnYan CuiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Miao Yu Gang Guo Lei Huang Libin Deng Chang-Sheng Chang Bhagelu R. Achyut Madison Canning Ningchun Xu Ali S. Arbab Roni J. Bollag Paulo C. Rodriguez Andrew L. Mellor Huidong Shi David H. Munn Yan Cui CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
description	Our understanding on how CAFs can be activated to support tumour progression is still limited. Here, the authors demonstrate that adenosine produced in the tumour microenvironment can enhance the expression of CD73 in CAFs ultimately driving CD8 T-Cell suppression and tumour growth.
format	article
author	Miao Yu Gang Guo Lei Huang Libin Deng Chang-Sheng Chang Bhagelu R. Achyut Madison Canning Ningchun Xu Ali S. Arbab Roni J. Bollag Paulo C. Rodriguez Andrew L. Mellor Huidong Shi David H. Munn Yan Cui
author_facet	Miao Yu Gang Guo Lei Huang Libin Deng Chang-Sheng Chang Bhagelu R. Achyut Madison Canning Ningchun Xu Ali S. Arbab Roni J. Bollag Paulo C. Rodriguez Andrew L. Mellor Huidong Shi David H. Munn Yan Cui
author_sort	Miao Yu
title	CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
title_short	CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
title_full	CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
title_fullStr	CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
title_full_unstemmed	CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint
title_sort	cd73 on cancer-associated fibroblasts enhanced by the a2b-mediated feedforward circuit enforces an immune checkpoint
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3a939ed9e1ba46adb3d1e889423e5b4d
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CD73 on cancer-associated fibroblasts enhanced by the A2B-mediated feedforward circuit enforces an immune checkpoint

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