Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans

Abstract In nematode Caenorhabditis elegans, some microRNAs (miRNAs) could be dysregulated by multi-walled carbon nanotubes (MWCNTs), suggesting their involvement in regulating the response of nematodes to MWCNTs. Among these dysregulated miRNAs induced by MWCNT exposure, prolonged exposure to MWCNT...

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Autores principales:	Yunli Zhao, Ling Jin, Yuan Wang, Yan Kong, Dayong Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3a94842d59cd45ec9e810062b2195a16
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spelling	oai:doaj.org-article:3a94842d59cd45ec9e810062b2195a162021-12-02T15:08:46ZProlonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans10.1038/s41598-019-48646-82045-2322https://doaj.org/article/3a94842d59cd45ec9e810062b2195a162019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48646-8https://doaj.org/toc/2045-2322Abstract In nematode Caenorhabditis elegans, some microRNAs (miRNAs) could be dysregulated by multi-walled carbon nanotubes (MWCNTs), suggesting their involvement in regulating the response of nematodes to MWCNTs. Among these dysregulated miRNAs induced by MWCNT exposure, prolonged exposure to MWCNTs increased mir-35 expression. mir-35 further acted in the intestine to regulate the response to MWCNTs. In the intestine, a transcription factor MAB-3 was identified as its target in regulating the response to MWCNTs. Moreover, during the control of response to MWCNTs, MAB-3 acted upstream of DAF-16, a fork head transcriptional factor in insulin signaling pathway. Therefore, MWCNTs exposure potentially dysregulates intestinal mir-35 and its direct target MAB-3, which may activate a protective intestinal response of nematodes against the MWCNTs toxicity.Yunli ZhaoLing JinYuan WangYan KongDayong WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yunli Zhao Ling Jin Yuan Wang Yan Kong Dayong Wang Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
description	Abstract In nematode Caenorhabditis elegans, some microRNAs (miRNAs) could be dysregulated by multi-walled carbon nanotubes (MWCNTs), suggesting their involvement in regulating the response of nematodes to MWCNTs. Among these dysregulated miRNAs induced by MWCNT exposure, prolonged exposure to MWCNTs increased mir-35 expression. mir-35 further acted in the intestine to regulate the response to MWCNTs. In the intestine, a transcription factor MAB-3 was identified as its target in regulating the response to MWCNTs. Moreover, during the control of response to MWCNTs, MAB-3 acted upstream of DAF-16, a fork head transcriptional factor in insulin signaling pathway. Therefore, MWCNTs exposure potentially dysregulates intestinal mir-35 and its direct target MAB-3, which may activate a protective intestinal response of nematodes against the MWCNTs toxicity.
format	article
author	Yunli Zhao Ling Jin Yuan Wang Yan Kong Dayong Wang
author_facet	Yunli Zhao Ling Jin Yuan Wang Yan Kong Dayong Wang
author_sort	Yunli Zhao
title	Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
title_short	Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
title_full	Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
title_fullStr	Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
title_full_unstemmed	Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans
title_sort	prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target mab-3 in nematode caenorhabditis elegans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3a94842d59cd45ec9e810062b2195a16
work_keys_str_mv	AT yunlizhao prolongedexposuretomultiwalledcarbonnanotubesdysregulatesintestinalmir35anditsdirecttargetmab3innematodecaenorhabditiselegans AT lingjin prolongedexposuretomultiwalledcarbonnanotubesdysregulatesintestinalmir35anditsdirecttargetmab3innematodecaenorhabditiselegans AT yuanwang prolongedexposuretomultiwalledcarbonnanotubesdysregulatesintestinalmir35anditsdirecttargetmab3innematodecaenorhabditiselegans AT yankong prolongedexposuretomultiwalledcarbonnanotubesdysregulatesintestinalmir35anditsdirecttargetmab3innematodecaenorhabditiselegans AT dayongwang prolongedexposuretomultiwalledcarbonnanotubesdysregulatesintestinalmir35anditsdirecttargetmab3innematodecaenorhabditiselegans
_version_	1718387992079368192

Prolonged exposure to multi-walled carbon nanotubes dysregulates intestinal mir-35 and its direct target MAB-3 in nematode Caenorhabditis elegans

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