A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either 64CuCl2 or 64CuPSMA PET/CT

Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods:...

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Autores principales:	Adriana Faiella, Rosa Sciuto, Diana Giannarelli, Marta Bottero, Alessia Farneti, Luca Bertini, Sandra Rea, Valeria Landoni, Patrizia Vici, Maria Consiglia Ferriero, Giuseppe Sanguineti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer salvage radiotherapy PET/CT multiparametric MR Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/3a94b73a48df428080fa840f9513d63e
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spelling	oai:doaj.org-article:3a94b73a48df428080fa840f9513d63e2021-11-11T15:35:16ZA Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT10.3390/cancers132155642072-6694https://doaj.org/article/3a94b73a48df428080fa840f9513d63e2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5564https://doaj.org/toc/2072-6694Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods: The present prospective study was conducted at a single institution between August 2017 and June 2020. Eligibility criteria were undetectable PSA after RP; subsequent biochemical recurrence (two consecutive PSA rises to 0.2 ng/mL or greater); a presumed local failure at mpMR; no distant metastases at <sup>18</sup>F-fluorocholine PET/CT (CH/PET); no previous history of androgen deprivation therapy. Patients were offered both <sup>64</sup>CuCl<sub>2</sub> PET/CT (CU/PET) and <sup>64</sup>Cu-PSMA PET/CT (PSMA/PET) before sRT. After image co-registration, PET findings were compared to mpMR ones in terms of DR and independent predictors of DR investigated at logistic regression. Results: A total of 62 patients with 72 nodules at mpMR were accrued. Compared to mpMR (DR = 100%, 95%CI: 94.9–100%), DRs were 47.2% (95%CI: 36.1–58.6%) and 54.4% (95%CI: 42.7–65.7%) for CU/PET and PSMA/PET, respectively (<i>p</i> < 0.001 for both). Both experimental PET/CT performed particularly poorly at PSA levels consistent with early sRT. Conclusions: The two novel radiotracers are inferior to mpMR in restaging the prostatic fossa for sRT planning purposes, particularly in the context of early salvage radiotherapy.Adriana FaiellaRosa SciutoDiana GiannarelliMarta BotteroAlessia FarnetiLuca BertiniSandra ReaValeria LandoniPatrizia ViciMaria Consiglia FerrieroGiuseppe SanguinetiMDPI AGarticleprostate cancersalvage radiotherapyPET/CTmultiparametric MRNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5564, p 5564 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer salvage radiotherapy PET/CT multiparametric MR Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer salvage radiotherapy PET/CT multiparametric MR Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Adriana Faiella Rosa Sciuto Diana Giannarelli Marta Bottero Alessia Farneti Luca Bertini Sandra Rea Valeria Landoni Patrizia Vici Maria Consiglia Ferriero Giuseppe Sanguineti A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
description	Background: We aimed assess the detection rate (DR) of positron emission tomography/computed tomography with two novel tracers in patients referred for salvage radiotherapy (sRT) with a presumed local recurrence at multiparametric magnetic resonance (mpMR) after radical prostatectomy (RP). Methods: The present prospective study was conducted at a single institution between August 2017 and June 2020. Eligibility criteria were undetectable PSA after RP; subsequent biochemical recurrence (two consecutive PSA rises to 0.2 ng/mL or greater); a presumed local failure at mpMR; no distant metastases at <sup>18</sup>F-fluorocholine PET/CT (CH/PET); no previous history of androgen deprivation therapy. Patients were offered both <sup>64</sup>CuCl<sub>2</sub> PET/CT (CU/PET) and <sup>64</sup>Cu-PSMA PET/CT (PSMA/PET) before sRT. After image co-registration, PET findings were compared to mpMR ones in terms of DR and independent predictors of DR investigated at logistic regression. Results: A total of 62 patients with 72 nodules at mpMR were accrued. Compared to mpMR (DR = 100%, 95%CI: 94.9–100%), DRs were 47.2% (95%CI: 36.1–58.6%) and 54.4% (95%CI: 42.7–65.7%) for CU/PET and PSMA/PET, respectively (<i>p</i> < 0.001 for both). Both experimental PET/CT performed particularly poorly at PSA levels consistent with early sRT. Conclusions: The two novel radiotracers are inferior to mpMR in restaging the prostatic fossa for sRT planning purposes, particularly in the context of early salvage radiotherapy.
format	article
author	Adriana Faiella Rosa Sciuto Diana Giannarelli Marta Bottero Alessia Farneti Luca Bertini Sandra Rea Valeria Landoni Patrizia Vici Maria Consiglia Ferriero Giuseppe Sanguineti
author_facet	Adriana Faiella Rosa Sciuto Diana Giannarelli Marta Bottero Alessia Farneti Luca Bertini Sandra Rea Valeria Landoni Patrizia Vici Maria Consiglia Ferriero Giuseppe Sanguineti
author_sort	Adriana Faiella
title	A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
title_short	A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
title_full	A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
title_fullStr	A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
title_full_unstemmed	A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT
title_sort	prospective study assessing the post-prostatectomy detection rate of a presumed local failure at mpmr with either <sup>64</sup>cucl<sub>2</sub> or <sup>64</sup>cupsma pet/ct
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/3a94b73a48df428080fa840f9513d63e
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A Prospective Study Assessing the Post-Prostatectomy Detection Rate of a Presumed Local Failure at mpMR with Either <sup>64</sup>CuCl<sub>2</sub> or <sup>64</sup>CuPSMA PET/CT

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